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Arias-Stella reaction, also Arias-Stella phenomenon, is a benign change in the endometrium associated with the presence of chorionic tissue. [1]
Arias-Stella reaction is due to progesterone primarily. Cytologically, it looks like a malignancy and, historically, it was diagnosed as endometrial cancer. [1]
Significance
It is significant only because it can be misdiagnosed as a cancer. It may be seen in a completely normal pregnancy.
Diagnosis
It is characterized by nuclear enlargement and may also have any of the following: an irregular nuclear membrane, granular chromatin, centronuclear vacuolization, and pseudonuclear inclusions. [1]
Five subtypes are recognized: [1]
- Minimal atypia.
- Early secretory pattern.
- Secretory or hypersecretory pattern.
- Regenerative, proliferative or nonsecretory pattern.
- Monstrous cell pattern.
History
It was first described by Javier Arias Stella, a Peruvian pathologist, in 1954. [2]
See also
Molar ectopic
References
- ^ a b c d Arias-Stella, J. (Jan 2002). "The Arias-Stella reaction: facts and fancies four decades after". Adv Anat Pathol. 9 (1): 12–23. doi: 10.1097/00125480-200201000-00003. PMID 11756756. S2CID 26249687.
- ^ Arias-Stella, J. (Aug 1954). "Atypical endometrial changes associated with the presence of chorionic tissue". Arch Pathol. 58 (2): 112–28. PMID 13170908.
Bibliography
- Textbook of Obstetrics by D.C. Dutta Page no. 180. ISBN 81-7381-142-3
Arias-Stella reaction, also Arias-Stella phenomenon, is a benign change in the endometrium associated with the presence of chorionic tissue. [1]
Arias-Stella reaction is due to progesterone primarily. Cytologically, it looks like a malignancy and, historically, it was diagnosed as endometrial cancer. [1]
Significance
It is significant only because it can be misdiagnosed as a cancer. It may be seen in a completely normal pregnancy.
Diagnosis
It is characterized by nuclear enlargement and may also have any of the following: an irregular nuclear membrane, granular chromatin, centronuclear vacuolization, and pseudonuclear inclusions. [1]
Five subtypes are recognized: [1]
- Minimal atypia.
- Early secretory pattern.
- Secretory or hypersecretory pattern.
- Regenerative, proliferative or nonsecretory pattern.
- Monstrous cell pattern.
History
It was first described by Javier Arias Stella, a Peruvian pathologist, in 1954. [2]
See also
Molar ectopic
References
- ^ a b c d Arias-Stella, J. (Jan 2002). "The Arias-Stella reaction: facts and fancies four decades after". Adv Anat Pathol. 9 (1): 12–23. doi: 10.1097/00125480-200201000-00003. PMID 11756756. S2CID 26249687.
- ^ Arias-Stella, J. (Aug 1954). "Atypical endometrial changes associated with the presence of chorionic tissue". Arch Pathol. 58 (2): 112–28. PMID 13170908.
Bibliography
- Textbook of Obstetrics by D.C. Dutta Page no. 180. ISBN 81-7381-142-3