Clinical data | |
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Trade names | HyperTET S/D, others |
Other names | tetanus immune globulin, tetanus antitoxin |
AHFS/ Drugs.com | Monograph |
Routes of administration | IM |
Identifiers | |
CAS Number | |
ChemSpider |
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Anti-tetanus immunoglobulin, also known as tetanus immune globulin (TIG) and tetanus antitoxin, is a medication made up of antibodies against the tetanus toxin. [1] It is used to prevent tetanus in those who have a wound that is at high risk, have not been fully vaccinated with tetanus toxoid, or have HIV/AIDS. [1] [2] It is used to treat tetanus along with antibiotics and muscle relaxants. [1] It is given by injection into a muscle. [1] Part of the dose is injected at the site of the wound. [2]
Common side effects include pain at the site of injection and fever. [1] Allergic reactions including anaphylaxis may rarely occur. [1] There is also a very low risk of the spread of infections such as viral hepatitis and HIV/AIDS with the human version. [1] Use during pregnancy and lactation is acceptable. [3] [4] It is made from either human or horse blood plasma. [1] [5]
The immunoglobulin is categorized as immunoglobulin G (IgG). [4] Since the tetanus toxin permanently binds to human tissues, only unbounded molecules can be neutralized by the immunoglobulin. [2]
Use of the horse version became common in the 1910s, while the human version came into frequent use in the 1960s. [6] It is on the World Health Organization's List of Essential Medicines. [7] [8] The human version may be unavailable in the developing world. [5] The horse version is not typically used in the developed world due to the risk of serum sickness. [9]
Clinical data | |
---|---|
Trade names | HyperTET S/D, others |
Other names | tetanus immune globulin, tetanus antitoxin |
AHFS/ Drugs.com | Monograph |
Routes of administration | IM |
Identifiers | |
CAS Number | |
ChemSpider |
|
Anti-tetanus immunoglobulin, also known as tetanus immune globulin (TIG) and tetanus antitoxin, is a medication made up of antibodies against the tetanus toxin. [1] It is used to prevent tetanus in those who have a wound that is at high risk, have not been fully vaccinated with tetanus toxoid, or have HIV/AIDS. [1] [2] It is used to treat tetanus along with antibiotics and muscle relaxants. [1] It is given by injection into a muscle. [1] Part of the dose is injected at the site of the wound. [2]
Common side effects include pain at the site of injection and fever. [1] Allergic reactions including anaphylaxis may rarely occur. [1] There is also a very low risk of the spread of infections such as viral hepatitis and HIV/AIDS with the human version. [1] Use during pregnancy and lactation is acceptable. [3] [4] It is made from either human or horse blood plasma. [1] [5]
The immunoglobulin is categorized as immunoglobulin G (IgG). [4] Since the tetanus toxin permanently binds to human tissues, only unbounded molecules can be neutralized by the immunoglobulin. [2]
Use of the horse version became common in the 1910s, while the human version came into frequent use in the 1960s. [6] It is on the World Health Organization's List of Essential Medicines. [7] [8] The human version may be unavailable in the developing world. [5] The horse version is not typically used in the developed world due to the risk of serum sickness. [9]