Anti-cholesterol is a naturally occurring
antibody to
cholesterol produced by mammals. This antibody serves a ‘housekeeping’ or protective role for the host animal, helping to protect the animal from harmful forms of cholesterol such as
LDL and
VLDL.
Modes of Action
An immunoglobulin protein, anti-cholesterol may be found both in circulation as well as in the digestive tract.
In circulation, this antibody binds selectively to the small, dense, oxidized cholesterol or
oxysterol rich LDLs that are known to contribute to the development of
atherosclerosis. The antibody does not bind the good forms of cholesterol such as
HDL.
Horváth A, Füst G, Horváth I, et al. (May 2001). "Anti-cholesterol antibodies (ACHA) in patients with different atherosclerotic vascular diseases and healthy individuals. Characterization of human ACHA". Atherosclerosis. 156 (1): 185–92.
doi:
10.1016/s0021-9150(00)00630-4.
PMID11369013.
Anti-cholesterol is a naturally occurring
antibody to
cholesterol produced by mammals. This antibody serves a ‘housekeeping’ or protective role for the host animal, helping to protect the animal from harmful forms of cholesterol such as
LDL and
VLDL.
Modes of Action
An immunoglobulin protein, anti-cholesterol may be found both in circulation as well as in the digestive tract.
In circulation, this antibody binds selectively to the small, dense, oxidized cholesterol or
oxysterol rich LDLs that are known to contribute to the development of
atherosclerosis. The antibody does not bind the good forms of cholesterol such as
HDL.
Horváth A, Füst G, Horváth I, et al. (May 2001). "Anti-cholesterol antibodies (ACHA) in patients with different atherosclerotic vascular diseases and healthy individuals. Characterization of human ACHA". Atherosclerosis. 156 (1): 185–92.
doi:
10.1016/s0021-9150(00)00630-4.
PMID11369013.