It has been suggested that
talfirastide be
merged into this article. (
Discuss) Proposed since December 2023. |
Angiotensin (1-7) | |
---|---|
Identifiers | |
Symbol | Angiotensin (1-7) |
SCOP2 | 2PJ8 / SCOPe / SUPFAM |
Angiotensin (1-7) (C
41H
62N
12O
11; Molecular weight = 899.02 g/mol; H-
Asp-
Arg-
Val-
Tyr-
Ile-
His-
Pro-OH) is an active
heptapeptide of the
renin–angiotensin system (RAS).[
citation needed]
In 1988, Santos et al demonstrated that angiotensin (1-7) was a main product of the incubation of angiotensin I with brain micropunch biopsies [1] and Schiavone et al reported the first biological effect of this heptapeptide. [2]
Angiotensin (1-7) is a vasodilator agent affecting cardiovascular organs, such as heart, blood vessels and kidneys, with functions frequently opposed to those attributed to the major effector component of the RAS, angiotensin II (Ang II). [3]
The polypeptide Ang I can be converted into Ang (1-7) by the actions of neprilysin (NEP) [4] and thimet oligopeptidase (TOP) [5] enzymes. Also, Ang II can be hydrolyzed into Ang (1-7) through the actions of angiotensin-converting enzyme 2 (ACE2). Ang (1-7) binds and activates the G-protein coupled receptor Mas receptor [6] leading to opposite effects of those of Ang II.
Ang (1-7) has been shown to have anti-oxidant and anti-inflammatory effects. [7] [8] It helps protect cardiomyocytes of spontaneously hypertensive rats by increasing the expression of endothelial and neuronal nitric oxide synthase enzymes, augmenting production of nitric oxide. [9]
Ang (1-7) contributes to the beneficial effects of ACE inhibitors and angiotensin II receptor type 1 antagonists. [10]
It has been suggested that
talfirastide be
merged into this article. (
Discuss) Proposed since December 2023. |
Angiotensin (1-7) | |
---|---|
Identifiers | |
Symbol | Angiotensin (1-7) |
SCOP2 | 2PJ8 / SCOPe / SUPFAM |
Angiotensin (1-7) (C
41H
62N
12O
11; Molecular weight = 899.02 g/mol; H-
Asp-
Arg-
Val-
Tyr-
Ile-
His-
Pro-OH) is an active
heptapeptide of the
renin–angiotensin system (RAS).[
citation needed]
In 1988, Santos et al demonstrated that angiotensin (1-7) was a main product of the incubation of angiotensin I with brain micropunch biopsies [1] and Schiavone et al reported the first biological effect of this heptapeptide. [2]
Angiotensin (1-7) is a vasodilator agent affecting cardiovascular organs, such as heart, blood vessels and kidneys, with functions frequently opposed to those attributed to the major effector component of the RAS, angiotensin II (Ang II). [3]
The polypeptide Ang I can be converted into Ang (1-7) by the actions of neprilysin (NEP) [4] and thimet oligopeptidase (TOP) [5] enzymes. Also, Ang II can be hydrolyzed into Ang (1-7) through the actions of angiotensin-converting enzyme 2 (ACE2). Ang (1-7) binds and activates the G-protein coupled receptor Mas receptor [6] leading to opposite effects of those of Ang II.
Ang (1-7) has been shown to have anti-oxidant and anti-inflammatory effects. [7] [8] It helps protect cardiomyocytes of spontaneously hypertensive rats by increasing the expression of endothelial and neuronal nitric oxide synthase enzymes, augmenting production of nitric oxide. [9]
Ang (1-7) contributes to the beneficial effects of ACE inhibitors and angiotensin II receptor type 1 antagonists. [10]