Amnesiac neuropeptides | |||||||
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Identifiers | |||||||
Organism | |||||||
Symbol | amn | ||||||
UniProt | Q24049 | ||||||
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The amnesiac (amn) gene in Drosophila is a mutant suppressor of the dunce gene. The gene produces a neuropeptide [1] [2] [3] of the same name. [4]
By suppressing dunce through mutagenesis, the amnesiac gene plays a role in reproduction of Drosophila because dunce is the sterility gene. [3] [5] This molecule has similar peptides to pituitary adenylyl cyclase-activating peptide (PACAP) and growth hormone-releasing hormone (GHRH). [2] [3] The biological role of amnesiac gene is activating the adenyl cyclase second messenger pathway (cAMP) involved in its memory retrieval through these two peptides. [1] [2] [5] [6] The sensory and motor capabilities of amnesiac are normal, but it is memory retrieval that is affected, not storage. [7] The amnesiac gene is directly involved in development of memory retrieval in the brain along with alcohol sensitivity patterning. [1] [6]
Defects associated with amnesiac gene include: increased sensitivity to alcohol, [6] normal initial memory, and failure for adult memory formation. [5] Defects associated with amnesiac are due to the behavior of amn as a sex-linked recessive on the X chromosome. [7] An abnormality on one allele of the genetic mutant, amnesiac, that increases sensitivity to alcohol is called cheapdate. [2] [6] Scientists have not generated a knockout model yet for the amnesiac gene due to the mutant effects created on multiple genes along with the need for further research studies about the amnesiac gene.
Amnesiac neuropeptides | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Organism | |||||||
Symbol | amn | ||||||
UniProt | Q24049 | ||||||
|
The amnesiac (amn) gene in Drosophila is a mutant suppressor of the dunce gene. The gene produces a neuropeptide [1] [2] [3] of the same name. [4]
By suppressing dunce through mutagenesis, the amnesiac gene plays a role in reproduction of Drosophila because dunce is the sterility gene. [3] [5] This molecule has similar peptides to pituitary adenylyl cyclase-activating peptide (PACAP) and growth hormone-releasing hormone (GHRH). [2] [3] The biological role of amnesiac gene is activating the adenyl cyclase second messenger pathway (cAMP) involved in its memory retrieval through these two peptides. [1] [2] [5] [6] The sensory and motor capabilities of amnesiac are normal, but it is memory retrieval that is affected, not storage. [7] The amnesiac gene is directly involved in development of memory retrieval in the brain along with alcohol sensitivity patterning. [1] [6]
Defects associated with amnesiac gene include: increased sensitivity to alcohol, [6] normal initial memory, and failure for adult memory formation. [5] Defects associated with amnesiac are due to the behavior of amn as a sex-linked recessive on the X chromosome. [7] An abnormality on one allele of the genetic mutant, amnesiac, that increases sensitivity to alcohol is called cheapdate. [2] [6] Scientists have not generated a knockout model yet for the amnesiac gene due to the mutant effects created on multiple genes along with the need for further research studies about the amnesiac gene.