Alpha-2-macroglobulin-like 1 abbreviated as α2ML1 is a
protein that in humans is encoded by the A2ML1
gene.[3] α2ML1 is a large, 180 kDa
protein found in the
epidermis. It is able to the inhibit the chymotryptic activity of
KLK7.[4]
Function
This gene encodes a member of the
alpha-macroglobulin superfamily. The encoded protein acts as an inhibitor for several
proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease
paraneoplastic pemphigus (PNP).[5] Alternative splicing results in multiple transcript variants.[3]
Alpha-2-macroglobulin-like 1 abbreviated as α2ML1 is a
protein that in humans is encoded by the A2ML1
gene.[3] α2ML1 is a large, 180 kDa
protein found in the
epidermis. It is able to the inhibit the chymotryptic activity of
KLK7.[4]
Function
This gene encodes a member of the
alpha-macroglobulin superfamily. The encoded protein acts as an inhibitor for several
proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease
paraneoplastic pemphigus (PNP).[5] Alternative splicing results in multiple transcript variants.[3]