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Alain Thierry (born 21 October 1959) is a French geneticist and cancer researcher. He specializes in the clinical applications of circulating DNA analysis, notably in cancer care management. He is currently Director of Research at the INSERM's Cancer Research Institute in Montpellier, France.

Education

Thierry obtained his primary degree in Cellular and Molecular Biology (MSc) at the University of Clermont-Ferrand ^[1] in France in 1982. In 1986 he completed his PhD in Biochemistry, Cellular and Molecular Pharmacology at the University of Montpellier II. ^[2] The following year he was awarded the Certificat d’Etudes Supérieures (CES) in Human Biology in Clinical and Experimental Oncology, from the Paris-Sud Faculty of Medicine.

Career

Thierry began his career in the US as a Postdoctoral Fellow (1988–92) at the Lombardi Cancer Centre in the Georgetown University Medical Centre (Washington DC), going on to work there as Adjunct Assistant Professor from 1992 to 1994. From 1992 to 1996 he was also a Visiting Scientist at the Laboratory of Tumor Cell Biology at the National Institutes of Health in Bethesda, where he worked with Dr. Robert C. Gallo, the laboratory's Director.

Returning to France, from 1997 to 2000 he served as Scientific Director at the Biovector Therapeutics company. From 2001 to 2007 he was Associate Professor ^[3] at Montpellier University's Faculty of Sciences. Since 2008, he has been the Senior Investigator and Director of Research at the INSERM's Cancer Research Institute of Montpellier (IRCM). ^[4]

He is the principal founder of the MedinCell and DiaDx biotech companies in France. The latter develops liquid biopsy solutions in oncology.

Research

Thierry specializes in the clinical application of liquid biopsy that exploits circulating DNA as a biomarker, notably in cancer management care. He has been the principal investigator in numerous discoveries in drug delivery innovation and application in oncology.

It was during his period at Georgetown that he showed the circumvention of multi-drug resistance in tumors through drug delivery. ^[5] There, he also developed his expertise in synthetic DNA complex formation, notably regarding its use for in vivo gene therapy. He built on this work at the US National Cancer Institute, ^[6] developing gene therapy for cancer and HIV, ^{[7] [8]} in particular the first long term expression of a transgene by systemic administration with a synthetic delivery system. ^[9]

While at the University of Montpellier, he worked first on the pharmacokinetics of therapeutic vectorized HIV antisense oligonucleotides in primates (2002). ^[10] He then went on to demonstrate the biomimetic supramolecular auto-organization of DNA in a synthetic complex (2006). ^[11]

Since 2006, Thierry has focused increasingly on clinical and basic research into the role of circulating DNA (cirDNA), and on its diagnostic potential in oncology. In this area, he has worked notably on: the detection of mutations following targeted therapy; the follow-up of CRC patients; and the prognostic power of cirDNA, with potential application in a universal cancer screening test. He has also worked towards the development of methods which support personalized medicine.

In 2009, his team developed an animal model to specifically quantify the different origins of cirDNA / circulating tumor DNA, and demonstrated the importance of short cirDNA fragment detection for high specificity and sensitivity in cirDNA analysis. ^{[12] [13]} That observation enabled dominant IP and the design of the IntPlex test, a multimarker quantitative analysis of cirDNA that also enables the detection of mutations. ^[14]

In 2014, Thierry coordinated the first prospective blinded multicenter study to offer clinical validation of plasma analysis in the detection of mutations in oncology, and to demonstrate the clinical utility of cirDNA analysis in digestive oncology. ^{[15] [16] [17]}

His team has also engaged in sustained basic research programs on cirDNA structure and functions. ^[18] Key discoveries in this area include the demonstration of the presence in blood of circulating functional cell-free mitochondria (2020), ^[19] and the demonstration that most cirDNA derives from neutrophil extracellular traps (NETs), either in the presence of invasive microorganisms or of cancer. ^[20] In a related discovery, they were amongst the first (in April 2020) to suggest NETs as a key player in COVID-19 pathogenesis (2020) ^[21] and have shown long COVID-19 (COVID post-acute phase syndrome) to be an effect of the persistence of the production of NETs and auto-antibodies. ^[22] Recently (2022), they have demonstrated cirDNA association with NETs production in cancer and lupus. ^[20]

Most recently, Thierry has pioneered work on cirDNA fragmentation, proposing potential solutions towards cancer screening through the use of fragmentomics. ^[23] This builds on earlier work (2011) on the fragmentation levels of cancer patient cirDNA. ^{[24] [13]}

According to Google Scholar, he has an h-index of 45. ^[25]

Awards and honors

• 2021: Innovation Prize, Montpellier Université d'Excellence (MUSE) ^[26]
• 2016: Grand Prix for Therapeutic Innovation, Beatrice Denys Foundation & the French Foundation for Medical Research (FRM). ^{[27] [28]}
• 2010: GEFLUC Award (Collective of French Companies against Cancer), France.
• 2002: National Innovation Award, French Ministry of Education & Research.
• 1994: Federal Technology Award, National Cancer Institute, National Institutes of Health, Bethesda, US.^{[ citation needed]}

References

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