Afadin is a
protein that in humans is encoded by the AFDNgene.[5]
Function
Afadin is a Ras (see HRAS; MIM 190020) target that regulates cell–cell adhesions downstream of Ras activation. It is fused with MLL (MIM 159555) in leukemias caused by t(6;11) translocations (Taya et al., 1998).[supplied by OMIM][6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Prasad R, Gu Y, Alder H, Nakamura T, Canaani O, Saito H, Huebner K, Gale RP, Nowell PC, Kuriyama K (Dec 1993). "Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation". Cancer Research. 53 (23): 5624–8.
PMID8242616.
^
abYamamoto T, Harada N, Kawano Y, Taya S, Kaibuchi K (May 1999). "In vivo interaction of AF-6 with activated Ras and ZO-1". Biochemical and Biophysical Research Communications. 259 (1): 103–7.
doi:
10.1006/bbrc.1999.0731.
PMID10334923.
^Bégay-Müller V, Ansieau S, Leutz A (Jun 2002). "The LIM domain protein Lmo2 binds to AF6, a translocation partner of the MLL oncogene". FEBS Letters. 521 (1–3): 36–8.
doi:
10.1016/s0014-5793(02)02814-4.
PMID12067721.
S2CID29461336.
^Reymond N, Borg JP, Lecocq E, Adelaide J, Campadelli-Fiume G, Dubreuil P, Lopez M (Sep 2000). "Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin". Gene. 255 (2): 347–55.
doi:
10.1016/s0378-1119(00)00316-4.
PMID11024295.
Saha V, Lillington DM, Shelling AN, Chaplin T, Yaspo ML, Ganesan TS, Young BD (Nov 1995). "AF6 gene on chromosome band 6q27 maps distal to the minimal region of deletion in epithelial ovarian cancer". Genes, Chromosomes & Cancer. 14 (3): 220–2.
doi:
10.1002/gcc.2870140311.
PMID8589040.
S2CID23752846.
Yamamoto T, Harada N, Kawano Y, Taya S, Kaibuchi K (May 1999). "In vivo interaction of AF-6 with activated Ras and ZO-1". Biochemical and Biophysical Research Communications. 259 (1): 103–7.
doi:
10.1006/bbrc.1999.0731.
PMID10334923.
Shao H, Kadono-Okuda K, Finlin BS, Andres DA (Nov 1999). "Biochemical characterization of the Ras-related GTPases Rit and Rin". Archives of Biochemistry and Biophysics. 371 (2): 207–19.
doi:
10.1006/abbi.1999.1448.
PMID10545207.
Afadin is a
protein that in humans is encoded by the AFDNgene.[5]
Function
Afadin is a Ras (see HRAS; MIM 190020) target that regulates cell–cell adhesions downstream of Ras activation. It is fused with MLL (MIM 159555) in leukemias caused by t(6;11) translocations (Taya et al., 1998).[supplied by OMIM][6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Prasad R, Gu Y, Alder H, Nakamura T, Canaani O, Saito H, Huebner K, Gale RP, Nowell PC, Kuriyama K (Dec 1993). "Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation". Cancer Research. 53 (23): 5624–8.
PMID8242616.
^
abYamamoto T, Harada N, Kawano Y, Taya S, Kaibuchi K (May 1999). "In vivo interaction of AF-6 with activated Ras and ZO-1". Biochemical and Biophysical Research Communications. 259 (1): 103–7.
doi:
10.1006/bbrc.1999.0731.
PMID10334923.
^Bégay-Müller V, Ansieau S, Leutz A (Jun 2002). "The LIM domain protein Lmo2 binds to AF6, a translocation partner of the MLL oncogene". FEBS Letters. 521 (1–3): 36–8.
doi:
10.1016/s0014-5793(02)02814-4.
PMID12067721.
S2CID29461336.
^Reymond N, Borg JP, Lecocq E, Adelaide J, Campadelli-Fiume G, Dubreuil P, Lopez M (Sep 2000). "Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin". Gene. 255 (2): 347–55.
doi:
10.1016/s0378-1119(00)00316-4.
PMID11024295.
Saha V, Lillington DM, Shelling AN, Chaplin T, Yaspo ML, Ganesan TS, Young BD (Nov 1995). "AF6 gene on chromosome band 6q27 maps distal to the minimal region of deletion in epithelial ovarian cancer". Genes, Chromosomes & Cancer. 14 (3): 220–2.
doi:
10.1002/gcc.2870140311.
PMID8589040.
S2CID23752846.
Yamamoto T, Harada N, Kawano Y, Taya S, Kaibuchi K (May 1999). "In vivo interaction of AF-6 with activated Ras and ZO-1". Biochemical and Biophysical Research Communications. 259 (1): 103–7.
doi:
10.1006/bbrc.1999.0731.
PMID10334923.
Shao H, Kadono-Okuda K, Finlin BS, Andres DA (Nov 1999). "Biochemical characterization of the Ras-related GTPases Rit and Rin". Archives of Biochemistry and Biophysics. 371 (2): 207–19.
doi:
10.1006/abbi.1999.1448.
PMID10545207.