SAM-dependent MTases superfamily | |
---|---|
Identifiers | |
Symbol | SAM-dependent_MTases |
InterPro | IPR029063 |
AdoMet_MTase | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
Symbol | AdoMet_MTase | ||||||||
Pfam | PF07757 | ||||||||
Pfam clan | CL0063 | ||||||||
InterPro | IPR011671 | ||||||||
|
S-adenosylmethionine-dependent methyltransferase (SAM-MTase or AdoMet-MTase) is a conserved protein domain and protein superfamily. [1] SAM-MTase proteins are methyltransferases. [2] There are five protein families within SAM-MTase,
SAM-MTases use S-adenosyl-L-methionine as a substrate for methylation, creating the product S-adenosyl-L-homocysteine. [3]
All SAM-MTases contain a structurally conserved SAM-binding domain consisting of a central seven-stranded beta-sheet that is flanked by three alpha-helices per side of the sheet. [4]
A review published in 2003 divides all methyltransferases into 5 main classes based on the structure of their catalytic domain (fold): [5]
SAM-dependent MTases superfamily | |
---|---|
Identifiers | |
Symbol | SAM-dependent_MTases |
InterPro | IPR029063 |
AdoMet_MTase | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
Symbol | AdoMet_MTase | ||||||||
Pfam | PF07757 | ||||||||
Pfam clan | CL0063 | ||||||||
InterPro | IPR011671 | ||||||||
|
S-adenosylmethionine-dependent methyltransferase (SAM-MTase or AdoMet-MTase) is a conserved protein domain and protein superfamily. [1] SAM-MTase proteins are methyltransferases. [2] There are five protein families within SAM-MTase,
SAM-MTases use S-adenosyl-L-methionine as a substrate for methylation, creating the product S-adenosyl-L-homocysteine. [3]
All SAM-MTases contain a structurally conserved SAM-binding domain consisting of a central seven-stranded beta-sheet that is flanked by three alpha-helices per side of the sheet. [4]
A review published in 2003 divides all methyltransferases into 5 main classes based on the structure of their catalytic domain (fold): [5]