Adermatoglyphia | |
---|---|
Other names | Immigration delay disease |
Adermatoglyphia is inherited in an autosomal dominant manner |
Adermatoglyphia is an extremely rare genetic disorder that prevents the development of fingerprints. Five extended families worldwide are known to be affected by this condition. [1] [2]
The disorder was informally nicknamed "immigration delay disease" by Professor Peter Itin after his first patient had trouble traveling to the U.S. without any fingerprints for identification. [3]
In 2007 an isolated finding was published regarding the description of a person from Switzerland who lacked fingerprints. [4] The phenotype was mapped to chromosome 4q22. In the splice-site of a 3' exon of the gene for SMARCAD1- helicase, a point mutation was detected. It results in a shortened form of the skin-specific protein. [5] The heterozygous expression of the mutation suggests an autosomal dominant mode of inheritance. [6] The Swiss patient, and eight of her relatives who also had the mutation, all had "flat finger pads and a reduced number of sweat glands in the hands". [7]
Other conditions can cause a lack of fingerprints, but unlike them, adermatoglyphia has no side effects. [8]
The medical condition and the 2007 Swiss medical case are both mentioned in the episode titled "She Was Murdered Twice" of the police drama television series Death in Paradise. [9]
Adermatoglyphia | |
---|---|
Other names | Immigration delay disease |
Adermatoglyphia is inherited in an autosomal dominant manner |
Adermatoglyphia is an extremely rare genetic disorder that prevents the development of fingerprints. Five extended families worldwide are known to be affected by this condition. [1] [2]
The disorder was informally nicknamed "immigration delay disease" by Professor Peter Itin after his first patient had trouble traveling to the U.S. without any fingerprints for identification. [3]
In 2007 an isolated finding was published regarding the description of a person from Switzerland who lacked fingerprints. [4] The phenotype was mapped to chromosome 4q22. In the splice-site of a 3' exon of the gene for SMARCAD1- helicase, a point mutation was detected. It results in a shortened form of the skin-specific protein. [5] The heterozygous expression of the mutation suggests an autosomal dominant mode of inheritance. [6] The Swiss patient, and eight of her relatives who also had the mutation, all had "flat finger pads and a reduced number of sweat glands in the hands". [7]
Other conditions can cause a lack of fingerprints, but unlike them, adermatoglyphia has no side effects. [8]
The medical condition and the 2007 Swiss medical case are both mentioned in the episode titled "She Was Murdered Twice" of the police drama television series Death in Paradise. [9]