Names | |
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Preferred IUPAC name
(6′R)-6′-Hydroxy-2′,4′,6′-trimethylspiro[cyclopropane-1,5′-inden]-7′(6′H)-one | |
Identifiers | |
3D model (
JSmol)
|
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ChEMBL | |
ChemSpider | |
PubChem
CID
|
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UNII | |
CompTox Dashboard (
EPA)
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Properties | |
C14H16O2 | |
Molar mass | 216.28 g/mol |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Acylfulvene is a class of cytotoxic semi-synthetic derivatives of illudin, a natural product that can be extracted from the jack o'lantern mushroom ( Omphalotus olearius). [1] One important acylfulvene, 6-hydroxymethylacylfulvene ( irofulven), has been evaluated for the treatment of a wide assortment of cancers and tumors. [2] It is thought that acylfulvene compounds kill cancer cells by DNA alkylation (see DNA methylation). [3]
Names | |
---|---|
Preferred IUPAC name
(6′R)-6′-Hydroxy-2′,4′,6′-trimethylspiro[cyclopropane-1,5′-inden]-7′(6′H)-one | |
Identifiers | |
3D model (
JSmol)
|
|
ChEMBL | |
ChemSpider | |
PubChem
CID
|
|
UNII | |
CompTox Dashboard (
EPA)
|
|
| |
| |
Properties | |
C14H16O2 | |
Molar mass | 216.28 g/mol |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Acylfulvene is a class of cytotoxic semi-synthetic derivatives of illudin, a natural product that can be extracted from the jack o'lantern mushroom ( Omphalotus olearius). [1] One important acylfulvene, 6-hydroxymethylacylfulvene ( irofulven), has been evaluated for the treatment of a wide assortment of cancers and tumors. [2] It is thought that acylfulvene compounds kill cancer cells by DNA alkylation (see DNA methylation). [3]