Acute panmyelosis with myelofibrosis | |
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Specialty | Hematology, oncology |
Acute panmyelosis with myelofibrosis (APMF) is a poorly defined disorder that arises as either a clonal disorder, or following toxic exposure to the bone marrow. [1]
Bone biopsy shows abnormal megakaryocytes, macrocytic erythropoiesis, and defects in neutrophil production and fibrosis of the marrow ( myelofibrosis).
Clinically, patients present with reduction in the count of all blood cells ( pancytopenia), very few blasts in the peripheral blood, and no or little spleen enlargement ( splenomegaly).
Cells are usually CD34 positive. [2]
Autologous stem cell transplantation has been used in treatment. [3]
Controversy remains today whether this disorder is a subtype of acute myeloid leukemia or myelodysplastic syndromes; however, it is currently classified as a form of AML. [4] [5]
Acute panmyelosis with myelofibrosis | |
---|---|
Specialty | Hematology, oncology |
Acute panmyelosis with myelofibrosis (APMF) is a poorly defined disorder that arises as either a clonal disorder, or following toxic exposure to the bone marrow. [1]
Bone biopsy shows abnormal megakaryocytes, macrocytic erythropoiesis, and defects in neutrophil production and fibrosis of the marrow ( myelofibrosis).
Clinically, patients present with reduction in the count of all blood cells ( pancytopenia), very few blasts in the peripheral blood, and no or little spleen enlargement ( splenomegaly).
Cells are usually CD34 positive. [2]
Autologous stem cell transplantation has been used in treatment. [3]
Controversy remains today whether this disorder is a subtype of acute myeloid leukemia or myelodysplastic syndromes; however, it is currently classified as a form of AML. [4] [5]