Antizyme inhibitor 1 is a
protein that in humans is encoded by the AZIN1gene.[5][6][7]
Ornithine decarboxylase (ODC)
catalyzes the conversion of
ornithine to
putrescine in the first and apparently
rate-limiting step in
polyaminebiosynthesis. Ornithine decarboxylase
antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. The protein encoded by this gene is highly similar to ODC. It binds to ODC antizyme and stabilizes ODC, thus inhibiting antizyme-mediated ODC degradation. Two alternatively spliced transcript variants have been found for this gene.[7]
Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res. 288 (1): 35–50.
doi:
10.1016/S0014-4827(03)00130-7.
PMID12878157.
Reuter TY, Medhurst AL, Waisfisz Q, et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21.
doi:
10.1016/S0014-4827(03)00261-1.
PMID14499622.
Antizyme inhibitor 1 is a
protein that in humans is encoded by the AZIN1gene.[5][6][7]
Ornithine decarboxylase (ODC)
catalyzes the conversion of
ornithine to
putrescine in the first and apparently
rate-limiting step in
polyaminebiosynthesis. Ornithine decarboxylase
antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. The protein encoded by this gene is highly similar to ODC. It binds to ODC antizyme and stabilizes ODC, thus inhibiting antizyme-mediated ODC degradation. Two alternatively spliced transcript variants have been found for this gene.[7]
Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res. 288 (1): 35–50.
doi:
10.1016/S0014-4827(03)00130-7.
PMID12878157.
Reuter TY, Medhurst AL, Waisfisz Q, et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21.
doi:
10.1016/S0014-4827(03)00261-1.
PMID14499622.