The human ATG4Dgene encodes the
proteinAutophagy related 4D, cysteine peptidase.[5]
Function
Autophagy is the process by which endogenous proteins and damaged
organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell
homeostasis and cell remodeling during differentiation,
metamorphosis, non-
apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant
tumors, and a role for autophagy in controlling the unregulated cell growth linked to
cancer has been proposed.
This gene belongs to the autophagy-related protein 4 (Atg4) family of C54
endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the
cytosol and organelles for degradation by
lysosomes. Alternative
splicing results in multiple
transcript variants. [provided by RefSeq, Jul 2013].
The human ATG4Dgene encodes the
proteinAutophagy related 4D, cysteine peptidase.[5]
Function
Autophagy is the process by which endogenous proteins and damaged
organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell
homeostasis and cell remodeling during differentiation,
metamorphosis, non-
apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant
tumors, and a role for autophagy in controlling the unregulated cell growth linked to
cancer has been proposed.
This gene belongs to the autophagy-related protein 4 (Atg4) family of C54
endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the
cytosol and organelles for degradation by
lysosomes. Alternative
splicing results in multiple
transcript variants. [provided by RefSeq, Jul 2013].