Cysteine protease ATG4A is an
enzyme that in humans is encoded by the ATG4Agene.[5][6]
Autophagy is the process by which
endogenous proteins and damaged
organelles are destroyed
intracellularly. Autophagy is postulated to be essential for cell
homeostasis and cell remodelling during
differentiation,
metamorphosis, non-
apoptoticcell death, and
aging. Reduced levels of autophagy have been described in some
malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the
autophagin protein family. The encoded protein is also designated as a member of the C-54 family of
cysteineproteases. Transcript variants that encode distinct
isoforms have been identified.[6]
Cysteine protease ATG4A is an
enzyme that in humans is encoded by the ATG4Agene.[5][6]
Autophagy is the process by which
endogenous proteins and damaged
organelles are destroyed
intracellularly. Autophagy is postulated to be essential for cell
homeostasis and cell remodelling during
differentiation,
metamorphosis, non-
apoptoticcell death, and
aging. Reduced levels of autophagy have been described in some
malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the
autophagin protein family. The encoded protein is also designated as a member of the C-54 family of
cysteineproteases. Transcript variants that encode distinct
isoforms have been identified.[6]