Activating transcription factor 7-interacting protein 1 is a
protein that in humans is encoded by the ATF7IPgene.[5][6][7]
Interactions
ATF7IP has been shown to
interact with
MBD1.[8] In mice with T cell-specific deletion of Atf7ip, the protein has been shown to play a role in regulating
T helper 17 cell (Th17) differentiation due to increased
IL-2 production upon stimulation of the
T cell receptor (TCR). This TCR stimulation occurs through deposition of
H3K9me3, a repressive
histone mark.[9][10]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Gunther M, Laithier M, Brison O (Dec 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Mol Cell Biochem. 210 (1–2): 131–42.
doi:
10.1023/A:1007177623283.
PMID10976766.
S2CID1339642.
^De Graeve F, Bahr A, Chatton B, Kedinger C (Jun 2000). "A murine ATFa-associated factor with transcriptional repressing activity". Oncogene. 19 (14): 1807–19.
doi:
10.1038/sj.onc.1203492.
PMID10777215.
S2CID22900736.
Morris JA, Kandpal G, Ma L, Austin CP (2004). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–608.
doi:
10.1093/hmg/ddg162.
PMID12812986.
PDBe-KB provides an overview of all the structure information available in the PDB for Human Activating transcription factor 7-interacting protein 1 (ATF7IP)
Activating transcription factor 7-interacting protein 1 is a
protein that in humans is encoded by the ATF7IPgene.[5][6][7]
Interactions
ATF7IP has been shown to
interact with
MBD1.[8] In mice with T cell-specific deletion of Atf7ip, the protein has been shown to play a role in regulating
T helper 17 cell (Th17) differentiation due to increased
IL-2 production upon stimulation of the
T cell receptor (TCR). This TCR stimulation occurs through deposition of
H3K9me3, a repressive
histone mark.[9][10]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Gunther M, Laithier M, Brison O (Dec 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Mol Cell Biochem. 210 (1–2): 131–42.
doi:
10.1023/A:1007177623283.
PMID10976766.
S2CID1339642.
^De Graeve F, Bahr A, Chatton B, Kedinger C (Jun 2000). "A murine ATFa-associated factor with transcriptional repressing activity". Oncogene. 19 (14): 1807–19.
doi:
10.1038/sj.onc.1203492.
PMID10777215.
S2CID22900736.
Morris JA, Kandpal G, Ma L, Austin CP (2004). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–608.
doi:
10.1093/hmg/ddg162.
PMID12812986.
PDBe-KB provides an overview of all the structure information available in the PDB for Human Activating transcription factor 7-interacting protein 1 (ATF7IP)