ARHGEF9

ARHGEF9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YSQ
Identifiers
Aliases	ARHGEF9, COLLYBISTIN, EIEE8, HPEM-2, PEM-2, PEM2, Cdc42 guanine nucleotide exchange factor 9, DEE8
External IDs	OMIM: 300429; MGI: 2442233; HomoloGene: 9053; GeneCards: ARHGEF9; OMA: ARHGEF9 - orthologs
Gene location ( Human)
Chr.	X chromosome (human)
End	63,809,274 bp
Gene location ( Mouse)
Chr.	X chromosome (mouse)
End	94,240,462 bp
RNA expression pattern
	Top expressed in
	Brodmann area 46; ; prefrontal cortex; ; Region I of hippocampus proper; ; nucleus accumbens; ; lateral nuclear group of thalamus; ; parietal lobe; ; superior frontal gyrus; ; postcentral gyrus; ; right frontal lobe; ; dorsolateral prefrontal cortex;
	Top expressed in
	superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; olfactory tubercle; ; piriform cortex; ; primary motor cortex; ; cerebellar cortex; ; lateral septal nucleus; ; hippocampus proper; ; globus pallidus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	guanyl-nucleotide exchange factor activity;
Cellular component	cytoplasm; cytosol; postsynaptic density; GABA-ergic synapse; plasma membrane; membrane; cell junction; synapse; postsynaptic membrane;
Biological process	positive regulation of apoptotic process; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; G protein-coupled receptor signaling pathway; regulation of postsynaptic specialization assembly;
	Sources: Amigo / QuickGO
Orthologs
	23229
	236915
	ENSG00000131089
	ENSMUSG00000025656
	O43307
	Q3UTH8
NM_001173479; NM_001173480; NM_015185; NM_001330495; NM_001353921;
	NM_001353922; NM_001353923; NM_001353924; NM_001353926; NM_001353927; NM_001353928; NM_001369030; NM_001369031; NM_001369032; NM_001369033; NM_001369034; NM_001369035; NM_001369036; NM_001369037; NM_001369038; NM_001369039; NM_001369040; NM_001369041; NM_001369042; NM_001369043; NM_001369044; NM_001369045
	NM_001033329; NM_001290384; NM_001290385
NP_001166950; NP_001166951; NP_001317424; NP_056000; NP_001340850;
	NP_001340851; NP_001340852; NP_001340853; NP_001340855; NP_001340856; NP_001340857; NP_001355959; NP_001355960; NP_001355961; NP_001355962; NP_001355963; NP_001355964; NP_001355965; NP_001355966; NP_001355967; NP_001355968; NP_001355969; NP_001355970; NP_001355971; NP_001355972; NP_001355973; NP_001355974
NP_001028501; NP_001277313; NP_001277314; NP_001392830; NP_001392831;
	NP_001392832; NP_001392833; NP_001392834; NP_001392835; NP_001392836; NP_001392837; NP_001392838; NP_001392839; NP_001392840; NP_001392841; NP_001392842; NP_001392843; NP_001392844; NP_001392845; NP_001392846; NP_001392847
	Wikidata
View/Edit Human	View/Edit Mouse

Rho guanine nucleotide exchange factor 9 is a protein that in humans is encoded by the ARHGEF9 gene.^[5]^[6]^[7]

Function

ARHGEF9 belongs to a family of Rho-like GTPases that act as molecular switches by cycling from the active GTP-bound state to the inactive GDP-bound state. These proteins are key regulators of the actin cytoskeleton and are involved in cell signaling.[supplied by OMIM]^[7]

Interactions

ARHGEF9 has been shown to interact with GPHN^[8] and SMURF1.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000131089 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025656 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Reid T, Bathoorn A, Ahmadian MR, Collard JG (Dec 1999). "Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42". J Biol Chem. 274 (47): 33587–93. doi: 10.1074/jbc.274.47.33587. PMID 10559246.
^ Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi: 10.1093/dnares/4.5.307. PMID 9455477.
^ ^a ^b "Entrez Gene: ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9".
^ Kins S, Betz H, Kirsch J (2000). "Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin". Nat. Neurosci. 3 (1): 22–9. doi: 10.1038/71096. PMID 10607391. S2CID 24878249.
^ Yamaguchi K, Ohara O, Ando A, Nagase T (Apr 2008). "Smurf1 directly targets hPEM-2, a GEF for Cdc42, via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway". Biol. Chem. 389 (4): 405–13. doi: 10.1515/BC.2008.036. PMID 18208356. S2CID 27505034.

External links

Human ARHGEF9 genome location and ARHGEF9 gene details page in the UCSC Genome Browser.

Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi: 10.1101/gr.2435604. PMC 515316. PMID 15342556.
Harvey K, Duguid IC, Alldred MJ, Beatty SE, Ward H, Keep NH, Lingenfelter SE, Pearce BR, Lundgren J, Owen MJ, Smart TG, Lüscher B, Rees MI, Harvey RJ (2004). "The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering" (PDF). J. Neurosci. 24 (25): 5816–26. doi: 10.1523/JNEUROSCI.1184-04.2004. PMC 6729214. PMID 15215304.
Grosskreutz Y, Hermann A, Kins S, Fuhrmann JC, Betz H, Kneussel M (2002). "Identification of a gephyrin-binding motif in the GDP/GTP exchange factor collybistin". Biol. Chem. 382 (10): 1455–62. doi: 10.1515/BC.2001.179. PMID 11727829. S2CID 2415901.
Kins S, Betz H, Kirsch J (2000). "Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin". Nat. Neurosci. 3 (1): 22–9. doi: 10.1038/71096. PMID 10607391. S2CID 24878249.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000131089 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025656 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10559246-5] Reid T, Bathoorn A, Ahmadian MR, Collard JG (Dec 1999). "Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42". J Biol Chem. 274 (47): 33587–93. doi: 10.1074/jbc.274.47.33587. PMID 10559246.

[pmid9455477-6] Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi: 10.1093/dnares/4.5.307. PMID 9455477.

[entrez-7] "Entrez Gene: ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9".

[pmid10607391-8] Kins S, Betz H, Kirsch J (2000). "Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin". Nat. Neurosci. 3 (1): 22–9. doi: 10.1038/71096. PMID 10607391. S2CID 24878249.

[pmid18208356-9] Yamaguchi K, Ohara O, Ando A, Nagase T (Apr 2008). "Smurf1 directly targets hPEM-2, a GEF for Cdc42, via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway". Biol. Chem. 389 (4): 405–13. doi: 10.1515/BC.2008.036. PMID 18208356. S2CID 27505034.

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Function

Interactions

References

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