ARHGDIA

ARHGDIA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CC0, 1FSO, 1FST, 1FT0, 1FT3, 1HH4, 1KMT, 1QVY, 1RHO, 2BXW, 2JHS, 2JHT, 2JHU, 2JHV, 2JHW, 2JHX, 2JHY, 2JHZ, 2JI0, 2N80
Identifiers
Aliases	ARHGDIA, GDIA1, HEL-S-47e, NPHS8, RHOGDI, RHOGDI-1, Rho GDP dissociation inhibitor alpha
External IDs	OMIM: 601925; MGI: 2178103; HomoloGene: 908; GeneCards: ARHGDIA; OMA: ARHGDIA - orthologs
Gene location ( Human)
Chr.	Chromosome 17 (human)
End	81,871,378 bp
Gene location ( Mouse)
Chr.	Chromosome 11 (mouse)
End	120,472,450 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; epithelium of colon; ; mucosa of transverse colon; ; left uterine tube; ; upper lobe of left lung; ; right lung; ; ascending aorta; ; left coronary artery; ; tibial nerve; ; anterior pituitary;
	Top expressed in
	tail of embryo; ; yolk sac; ; genital tubercle; ; tibiofemoral joint; ; lip; ; lactiferous gland; ; entorhinal cortex; ; mesenteric lymph nodes; ; perirhinal cortex; ; molar;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	GTPase activator activity; Rho GDP-dissociation inhibitor activity; protein binding;
Cellular component	cytoplasm; cytosol; extracellular exosome; cytoskeleton; membrane;
Biological process	negative regulation of cell adhesion; regulation of actin cytoskeleton reorganization; negative regulation of apoptotic process; positive regulation of axonogenesis; positive regulation of GTPase activity; negative regulation of axonogenesis; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; semaphorin-plexin signaling pathway; regulation of catalytic activity; Rho protein signal transduction;
	Sources: Amigo / QuickGO
Orthologs
	396
	192662
	ENSG00000141522
	ENSMUSG00000025132
	P52565
	Q99PT1
NM_001185077; NM_001185078; NM_001301240; NM_001301241; NM_001301242;
	NM_001301243; NM_004309
	NM_133796; NM_001363425
NP_001172006; NP_001172007; NP_001288169; NP_001288170; NP_001288171;
	NP_001288172; NP_004300
	NP_598557; NP_001350354
	Wikidata
View/Edit Human	View/Edit Mouse

Rho GDP-dissociation inhibitor 1 is a protein that in humans is encoded by the ARHGDIA gene.^[5]^[6]

Interactions

ARHGDIA has been shown to interact with:

CDC42,^[7]^[8]
RAC1,^[7]^[8]^[9]^[10]^[11]^[12]
RHOA,^[7]^[8]^[9]^[13]^[14]
Rac2,^[8]^[9] and
RhoH.^[9]^[15]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141522 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025132 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wagner T, Tommerup N, Wirth J, Leffers H, Zimmer J, Back E, Weissenbach J, Scherer G (July 1997). "A somatic cell hybrid panel for distal 17q: GDIA1 maps to 17q25.3". Cytogenet Cell Genet. 76 (3–4): 172–5. doi: 10.1159/000134538. PMID 9186513.
^ "Entrez Gene: ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha".
^ ^a ^b ^c Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi: 10.1038/msb4100134. PMC 1847948. PMID 17353931.
^ ^a ^b ^c ^d Gorvel JP, Chang TC, Boretto J, Azuma T, Chavrier P (January 1998). "Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity". FEBS Lett. 422 (2): 269–73. doi: 10.1016/s0014-5793(98)00020-9. PMID 9490022. S2CID 10817327.
^ ^a ^b ^c ^d Fauré J, Dagher MC (May 2001). "Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI)". Biochimie. 83 (5): 409–14. doi: 10.1016/s0300-9084(01)01263-9. PMID 11368848.
^ Grizot S, Fauré J, Fieschi F, Vignais PV, Dagher MC, Pebay-Peyroula E (August 2001). "Crystal structure of the Rac1-RhoGDI complex involved in nadph oxidase activation". Biochemistry. 40 (34): 10007–13. doi: 10.1021/bi010288k. PMID 11513578.
^ Lian LY, Barsukov I, Golovanov AP, Hawkins DI, Badii R, Sze KH, Keep NH, Bokoch GM, Roberts GC (January 2000). "Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1". Structure. 8 (1): 47–55. doi: 10.1016/s0969-2126(00)00080-0. PMID 10673424.
^ Di-Poï N, Fauré J, Grizot S, Molnár G, Pick E, Dagher MC (August 2001). "Mechanism of NADPH oxidase activation by the Rac/Rho-GDI complex". Biochemistry. 40 (34): 10014–22. doi: 10.1021/bi010289c. PMID 11513579.
^ Gajate C, Mollinedo F (March 2005). "Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy". J. Biol. Chem. 280 (12): 11641–7. doi: 10.1074/jbc.M411781200. PMID 15659383.
^ Michaelson D, Silletti J, Murphy G, D'Eustachio P, Rush M, Philips MR (January 2001). "Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding". J. Cell Biol. 152 (1): 111–26. doi: 10.1083/jcb.152.1.111. PMC 2193662. PMID 11149925.
^ Li X, Bu X, Lu B, Avraham H, Flavell RA, Lim B (February 2002). "The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function". Mol. Cell. Biol. 22 (4): 1158–71. doi: 10.1128/mcb.22.4.1158-1171.2002. PMC 134637. PMID 11809807.