From Wikipedia, the free encyclopedia
Mammalian protein found in Homo sapiens
ARG1
Available structures
PDB Ortholog search:
PDBe
RCSB List of PDB id codes
1WVA ,
1WVB ,
2AEB ,
2PHA ,
2PHO ,
2PLL ,
2ZAV ,
3DJ8 ,
3E6K ,
3E6V ,
3F80 ,
3GMZ ,
3GN0 ,
3KV2 ,
3LP4 ,
3LP7 ,
3MFV ,
3MFW ,
3MJL ,
3SJT ,
3SKK ,
3TF3 ,
3TH7 ,
3THE ,
3THH ,
3THJ ,
4FCI ,
4FCK ,
4GSM ,
4GSV ,
4GSZ ,
4GWC ,
4GWD ,
4HWW ,
4HXQ ,
4IE1
Identifiers
Aliases
ARG1 , arginase 1External IDs
OMIM :
608313 ;
MGI :
88070 ;
HomoloGene :
29 ;
GeneCards :
ARG1 ;
OMA :
ARG1 - orthologs
Wikidata
The human ARG1
gene encodes the
protein arginase .
[5]
Function
Arginase
catalyzes the
hydrolysis of
arginine to
ornithine and
urea . At least two
isoforms of
mammalian arginase exist (types I and II) which differ in their
tissue distribution, subcellular localization,
immunologic crossreactivity and
physiologic function. The type I isoform encoded by this gene, is a
cytosolic enzyme and expressed predominantly in the
liver as a component of the
urea cycle . Inherited deficiency of this enzyme results in
argininemia , an
autosomal recessive disorder characterized by
hyperammonemia . Two
transcript variants encoding different isoforms have been found for this gene.
[6]
References
External links
Further reading
Morris CR, Kato GJ, Poljakovic M, Wang X, Blackwelder WC, Sachdev V, Hazen SL, Vichinsky EP, Morris SM, Gladwin MT (July 2005).
"Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease" . JAMA . 294 (1): 81–90.
doi :
10.1001/jama.294.1.81 .
PMC
2065861 .
PMID
15998894 .
Jiang M, Ding Y, Su Y, Hu X, Li J, Zhang Z (December 2006). "Arginase-flotillin interaction brings arginase to red blood cell membrane". FEBS Letters . 580 (28–29): 6561–4.
doi :
10.1016/j.febslet.2006.11.003 .
PMID
17113085 .
S2CID
20180459 .
Morris SM (July 2009).
"Recent advances in arginine metabolism: roles and regulation of the arginases" . British Journal of Pharmacology . 157 (6): 922–30.
doi :
10.1111/j.1476-5381.2009.00278.x .
PMC
2737650 .
PMID
19508396 .
Rotondo R, Bertolotto M, Barisione G, Astigiano S, Mandruzzato S, Ottonello L, Dallegri F, Bronte V, Ferrini S, Barbieri O (May 2011).
"Exocytosis of azurophil and arginase 1-containing granules by activated polymorphonuclear neutrophils is required to inhibit T lymphocyte proliferation" . Journal of Leukocyte Biology . 89 (5): 721–7.
doi :
10.1189/jlb.1109737 .
PMID
21330347 .
S2CID
25335372 .
Shapiro MB, Senapathy P (September 1987).
"RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression" . Nucleic Acids Research . 15 (17): 7155–74.
doi :
10.1093/nar/15.17.7155 .
PMC
306199 .
PMID
3658675 .
Rotondo R, Barisione G, Mastracci L, Grossi F, Orengo AM, Costa R, Truini M, Fabbi M, Ferrini S, Barbieri O (August 2009). "IL-8 induces exocytosis of arginase 1 by neutrophil polymorphonuclears in nonsmall cell lung cancer". International Journal of Cancer . 125 (4): 887–93.
doi :
10.1002/ijc.24448 .
PMID
19431148 .
S2CID
205937936 .
Salam MT, Bastain TM, Rappaport EB, Islam T, Berhane K, Gauderman WJ, Gilliland FD (March 2011).
"Genetic variations in nitric oxide synthase and arginase influence exhaled nitric oxide levels in children" . Allergy . 66 (3): 412–9.
doi :
10.1111/j.1398-9995.2010.02492.x .
PMC
3058253 .
PMID
21039601 .
Gannon PO, Godin-Ethier J, Hassler M, Delvoye N, Aversa M, Poisson AO, Péant B, Alam Fahmy M, Saad F, Lapointe R, Mes-Masson AM (August 2010). Creighton C (ed.).
"Androgen-regulated expression of arginase 1, arginase 2 and interleukin-8 in human prostate cancer" . PLOS ONE . 5 (8): e12107.
Bibcode :
2010PLoSO...512107G .
doi :
10.1371/journal.pone.0012107 .
PMC
2920336 .
PMID
20711410 .
Ishikawa T, Harada T, Koi H, Kubota T, Azuma H, Aso T (2007). "Identification of arginase in human placental villi". Placenta . 28 (2–3): 133–8.
doi :
10.1016/j.placenta.2006.03.015 .
PMID
16720041 .
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .