This gene encodes an
apoptosis inhibitory protein whose expression prevents apoptosis after
growth factor deprivation. This protein suppresses the
transcription factorE2F1-induced apoptosis and also interacts with, and negatively regulates acinus, a
nuclear factor involved in apoptotic
DNA fragmentation. Its depletion enhances the
cytotoxic action of
chemotherapeutic drugs. Crystal structure of API5 exhibited the function for protein-protein interaction [7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R (September 1997). "AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal". Cancer Research. 57 (18): 4063–9.
PMID9307294.
Gianfrancesco F, Esposito T, Ciccodicola A, D'Esposito M, Mazzarella R, D'Urso M, Forabosco A (1999). "Molecular cloning and fine mapping of API5L1, a novel human gene strongly related to an antiapoptotic gene". Cytogenetics and Cell Genetics. 84 (3–4): 164–6.
doi:
10.1159/000015247.
PMID10393420.
S2CID44601647.
Li Z, Hu CY, Mo BQ, Xu JD, Zhao Y (April 2003). "[Effect of beta-carotene on gene expression of breast cancer cells]". AI Zheng = Aizheng = Chinese Journal of Cancer. 22 (4): 380–4.
PMID12703993.
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". Journal of Proteome Research. 4 (4): 1339–46.
doi:
10.1021/pr050048h.
PMID16083285.
This gene encodes an
apoptosis inhibitory protein whose expression prevents apoptosis after
growth factor deprivation. This protein suppresses the
transcription factorE2F1-induced apoptosis and also interacts with, and negatively regulates acinus, a
nuclear factor involved in apoptotic
DNA fragmentation. Its depletion enhances the
cytotoxic action of
chemotherapeutic drugs. Crystal structure of API5 exhibited the function for protein-protein interaction [7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R (September 1997). "AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal". Cancer Research. 57 (18): 4063–9.
PMID9307294.
Gianfrancesco F, Esposito T, Ciccodicola A, D'Esposito M, Mazzarella R, D'Urso M, Forabosco A (1999). "Molecular cloning and fine mapping of API5L1, a novel human gene strongly related to an antiapoptotic gene". Cytogenetics and Cell Genetics. 84 (3–4): 164–6.
doi:
10.1159/000015247.
PMID10393420.
S2CID44601647.
Li Z, Hu CY, Mo BQ, Xu JD, Zhao Y (April 2003). "[Effect of beta-carotene on gene expression of breast cancer cells]". AI Zheng = Aizheng = Chinese Journal of Cancer. 22 (4): 380–4.
PMID12703993.
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". Journal of Proteome Research. 4 (4): 1339–46.
doi:
10.1021/pr050048h.
PMID16083285.