10-formyltetrahydrofolate dehydrogenase is an
enzyme that in humans is encoded by the ALDH1L1gene.[5]
The protein encoded by this gene catalyzes the conversion of
10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (
NADP), and water to
tetrahydrofolate,
NADPH, and carbon dioxide. The encoded protein belongs to the
aldehyde dehydrogenase family and is responsible for
formate oxidation in vivo. Deficiencies in this gene can result in an accumulation of formate and subsequent
methanol poisoning.[5]
Stevens VL, McCullough ML, Pavluck AL, et al. (2007). "Association of polymorphisms in one-carbon metabolism genes and postmenopausal breast cancer incidence". Cancer Epidemiol. Biomarkers Prev. 16 (6): 1140–7.
doi:
10.1158/1055-9965.EPI-06-1037.
PMID17548676.
S2CID25945965.
Krupenko SA, Oleinik NV (2002). "10-formyltetrahydrofolate dehydrogenase, one of the major folate enzymes, is down-regulated in tumor tissues and possesses suppressor effects on cancer cells". Cell Growth Differ. 13 (5): 227–36.
PMID12065246.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Johlin FC, Swain E, Smith C, Tephly TR (1989). "Studies on the mechanism of methanol poisoning: purification and comparison of rat and human liver 10-formyltetrahydrofolate dehydrogenase". Mol. Pharmacol. 35 (6): 745–50.
PMID2733692.
10-formyltetrahydrofolate dehydrogenase is an
enzyme that in humans is encoded by the ALDH1L1gene.[5]
The protein encoded by this gene catalyzes the conversion of
10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (
NADP), and water to
tetrahydrofolate,
NADPH, and carbon dioxide. The encoded protein belongs to the
aldehyde dehydrogenase family and is responsible for
formate oxidation in vivo. Deficiencies in this gene can result in an accumulation of formate and subsequent
methanol poisoning.[5]
Stevens VL, McCullough ML, Pavluck AL, et al. (2007). "Association of polymorphisms in one-carbon metabolism genes and postmenopausal breast cancer incidence". Cancer Epidemiol. Biomarkers Prev. 16 (6): 1140–7.
doi:
10.1158/1055-9965.EPI-06-1037.
PMID17548676.
S2CID25945965.
Krupenko SA, Oleinik NV (2002). "10-formyltetrahydrofolate dehydrogenase, one of the major folate enzymes, is down-regulated in tumor tissues and possesses suppressor effects on cancer cells". Cell Growth Differ. 13 (5): 227–36.
PMID12065246.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Johlin FC, Swain E, Smith C, Tephly TR (1989). "Studies on the mechanism of methanol poisoning: purification and comparison of rat and human liver 10-formyltetrahydrofolate dehydrogenase". Mol. Pharmacol. 35 (6): 745–50.
PMID2733692.