From Wikipedia, the free encyclopedia
AKAP11
Identifiers
Aliases AKAP11, AKAP-11, AKAP220, PPP1R44, PRKA11, A-kinase anchoring protein 11
External IDs OMIM: 604696; MGI: 2684060; HomoloGene: 8279; GeneCards: AKAP11; OMA: AKAP11 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016248
NM_144490

NM_001164503
NM_001346784

RefSeq (protein)

NP_057332

n/a

Location (UCSC) Chr 13: 42.27 – 42.32 Mb Chr 14: 78.73 – 78.77 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

A-kinase anchor protein 11 is an enzyme that in humans is encoded by the AKAP11 gene. [5] [6] [7]

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function. [7]

Interactions

AKAP11 has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000023516Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022016Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (December 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169. PMID  9734811.
  6. ^ a b Lester LB, Coghlan VM, Nauert B, Scott JD (June 1996). "Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes" (PDF). J. Biol. Chem. 271 (16): 9460–5. doi: 10.1074/jbc.271.16.9460. PMID  8621616.
  7. ^ a b "Entrez Gene: AKAP11 A kinase (PRKA) anchor protein 11".
  8. ^ a b c Tanji C, Yamamoto H, Yorioka N, Kohno N, Kikuchi K, Kikuchi A (October 2002). "A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta". J. Biol. Chem. 277 (40): 36955–61. doi: 10.1074/jbc.M206210200. PMID  12147701.
  9. ^ Schillace RV, Scott JD (March 1999). "Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220". Curr. Biol. 9 (6): 321–4. Bibcode: 1999CBio....9..321S. doi: 10.1016/S0960-9822(99)80141-9. PMID  10209101.
  10. ^ Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD (April 2003). "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4445–50. Bibcode: 2003PNAS..100.4445A. doi: 10.1073/pnas.0330734100. PMC  153575. PMID  12672969.
  11. ^ Reinton N, Collas P, Haugen TB, Skâlhegg BS, Hansson V, Jahnsen T, Taskén K (July 2000). "Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis". Dev. Biol. 223 (1): 194–204. doi: 10.1006/dbio.2000.9725. PMID  10864471.
  12. ^ Huttlin EL, Ting L, Bruckner RJ, Gebreab F, Gygi MP, Szpyt J, et al. (2015). "The BioPlex Network: A Systematic Exploration of the Human Interactome". Cell. 162 (2): 425–40. doi: 10.1016/j.cell.2015.06.043. PMC  4617211. PMID  26186194.
  13. ^ Mikitova V, Levine TP (2012). "Analysis of the key elements of FFAT-like motifs identifies new proteins that potentially bind VAP on the ER, including two AKAPs and FAPP2". PLOS ONE. 7 (1): e30455. Bibcode: 2012PLoSO...730455M. doi: 10.1371/journal.pone.0030455. PMC  3261905. PMID  22276202.

External links

Further reading


From Wikipedia, the free encyclopedia
AKAP11
Identifiers
Aliases AKAP11, AKAP-11, AKAP220, PPP1R44, PRKA11, A-kinase anchoring protein 11
External IDs OMIM: 604696; MGI: 2684060; HomoloGene: 8279; GeneCards: AKAP11; OMA: AKAP11 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016248
NM_144490

NM_001164503
NM_001346784

RefSeq (protein)

NP_057332

n/a

Location (UCSC) Chr 13: 42.27 – 42.32 Mb Chr 14: 78.73 – 78.77 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

A-kinase anchor protein 11 is an enzyme that in humans is encoded by the AKAP11 gene. [5] [6] [7]

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function. [7]

Interactions

AKAP11 has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000023516Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022016Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (December 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169. PMID  9734811.
  6. ^ a b Lester LB, Coghlan VM, Nauert B, Scott JD (June 1996). "Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes" (PDF). J. Biol. Chem. 271 (16): 9460–5. doi: 10.1074/jbc.271.16.9460. PMID  8621616.
  7. ^ a b "Entrez Gene: AKAP11 A kinase (PRKA) anchor protein 11".
  8. ^ a b c Tanji C, Yamamoto H, Yorioka N, Kohno N, Kikuchi K, Kikuchi A (October 2002). "A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta". J. Biol. Chem. 277 (40): 36955–61. doi: 10.1074/jbc.M206210200. PMID  12147701.
  9. ^ Schillace RV, Scott JD (March 1999). "Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220". Curr. Biol. 9 (6): 321–4. Bibcode: 1999CBio....9..321S. doi: 10.1016/S0960-9822(99)80141-9. PMID  10209101.
  10. ^ Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD (April 2003). "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4445–50. Bibcode: 2003PNAS..100.4445A. doi: 10.1073/pnas.0330734100. PMC  153575. PMID  12672969.
  11. ^ Reinton N, Collas P, Haugen TB, Skâlhegg BS, Hansson V, Jahnsen T, Taskén K (July 2000). "Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis". Dev. Biol. 223 (1): 194–204. doi: 10.1006/dbio.2000.9725. PMID  10864471.
  12. ^ Huttlin EL, Ting L, Bruckner RJ, Gebreab F, Gygi MP, Szpyt J, et al. (2015). "The BioPlex Network: A Systematic Exploration of the Human Interactome". Cell. 162 (2): 425–40. doi: 10.1016/j.cell.2015.06.043. PMC  4617211. PMID  26186194.
  13. ^ Mikitova V, Levine TP (2012). "Analysis of the key elements of FFAT-like motifs identifies new proteins that potentially bind VAP on the ER, including two AKAPs and FAPP2". PLOS ONE. 7 (1): e30455. Bibcode: 2012PLoSO...730455M. doi: 10.1371/journal.pone.0030455. PMC  3261905. PMID  22276202.

External links

Further reading



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