Neuroblast differentiation-associated protein AHNAK, also known as desmoyokin, is a
protein that in humans is encoded by the AHNAKgene.[5][6][7] AHNAK was originally identified in 1989 (in
bovine muzzle
epidermal cells) and named desmoyokin due to its localization pattern (that resembled a
yoke) in the
desmosomal plaque.[8] AHNAK has been shown to be essential for
pseudopod protrusion and cell
migration.
[9]
Kudoh J, Wang Y, Minoshima S, Hashimoto T, Amagai M, Nishikawa T, Shtivelman E, Bishop JM, Shimizu N (1995). "Localization of the human AHNAK/desmoyokin gene (AHNAK) to chromosome band 11q12 by somatic cell hybrid analysis and fluorescence in situ hybridization". Cytogenetics and Cell Genetics. 70 (3–4): 218–20.
doi:
10.1159/000134037.
PMID7789175.
Wernyj RP, Ewing CM, Isaacs WB (October 2001). "Multiple antibodies to titin immunoreact with AHNAK and localize to the mitotic spindle machinery". Cell Motility and the Cytoskeleton. 50 (2): 101–13.
doi:
10.1002/cm.1044.
PMID11746675.
Stiff T, Shtivelman E, Jeggo P, Kysela B (March 2004). "AHNAK interacts with the DNA ligase IV-XRCC4 complex and stimulates DNA ligase IV-mediated double-stranded ligation". DNA Repair. 3 (3): 245–56.
doi:
10.1016/j.dnarep.2003.11.001.
PMID15177040.
Neuroblast differentiation-associated protein AHNAK, also known as desmoyokin, is a
protein that in humans is encoded by the AHNAKgene.[5][6][7] AHNAK was originally identified in 1989 (in
bovine muzzle
epidermal cells) and named desmoyokin due to its localization pattern (that resembled a
yoke) in the
desmosomal plaque.[8] AHNAK has been shown to be essential for
pseudopod protrusion and cell
migration.
[9]
Kudoh J, Wang Y, Minoshima S, Hashimoto T, Amagai M, Nishikawa T, Shtivelman E, Bishop JM, Shimizu N (1995). "Localization of the human AHNAK/desmoyokin gene (AHNAK) to chromosome band 11q12 by somatic cell hybrid analysis and fluorescence in situ hybridization". Cytogenetics and Cell Genetics. 70 (3–4): 218–20.
doi:
10.1159/000134037.
PMID7789175.
Wernyj RP, Ewing CM, Isaacs WB (October 2001). "Multiple antibodies to titin immunoreact with AHNAK and localize to the mitotic spindle machinery". Cell Motility and the Cytoskeleton. 50 (2): 101–13.
doi:
10.1002/cm.1044.
PMID11746675.
Stiff T, Shtivelman E, Jeggo P, Kysela B (March 2004). "AHNAK interacts with the DNA ligase IV-XRCC4 complex and stimulates DNA ligase IV-mediated double-stranded ligation". DNA Repair. 3 (3): 245–56.
doi:
10.1016/j.dnarep.2003.11.001.
PMID15177040.