From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma is an
enzyme that in humans is encoded by the AGPAT3
gene .
[5]
The protein encoded by this gene is an
acyltransferase (specifically,
1-acylglycerol-3-phosphate O-acyltransferase ) that converts
lysophosphatidic acid (1-acyl-sn -glycerol 3-phosphate) into
phosphatidic acid , which is the second step in the
de novo
phospholipid biosynthetic pathway . The encoded protein may be an
integral membrane protein . Two
transcript variants encoding the same protein have been found for this gene.
[5]
See also
References
External links
Further reading
Leung DW (2001).
"The structure and functions of human lysophosphatidic acid acyltransferases" . Front. Biosci . 6 : D944–53.
doi :
10.2741/Leung .
PMID
11487472 .
Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis . 8 : 185–95.
PMID
12107412 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Clark HF, Gurney AL, Abaya E, et al. (2003).
"The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment" . Genome Res . 13 (10): 2265–70.
doi :
10.1101/gr.1293003 .
PMC
403697 .
PMID
12975309 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Lu B, Jiang YJ, Zhou Y, et al. (2005).
"Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARα in murine heart" . Biochem. J . 385 (Pt 2): 469–77.
doi :
10.1042/BJ20041348 .
PMC
1134718 .
PMID
15367102 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Agarwal AK, Barnes RI, Garg A (2006). "Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity". Arch. Biochem. Biophys . 449 (1–2): 64–76.
doi :
10.1016/j.abb.2006.03.014 .
PMID
16620771 .
Hu YH, Warnatz HJ, Vanhecke D, et al. (2006).
"Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins" . BMC Genomics . 7 : 155.
doi :
10.1186/1471-2164-7-155 .
PMC
1526728 .
PMID
16780588 .