The human ADI1gene encodes the
enzyme1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase.[4][5][6]
Function
The enzyme belongs to the aci-reductone
dioxygenase family of metal-binding enzymes, which are involved in
methionine salvage. This enzyme may regulate
mRNA processing in the
nucleus, and may carry out different functions depending on its localization.
ADI1 is capable for supporting
hepatitis C virus replication in an otherwise non-permissive cell line.[7] Mouse hepatoma cells coexpressing human
CD81 and ADI1/Sip-L supported HCV infection and replication.[8] Human ADI1//Sip-L over-expression in 293 cells enhances cell entry but not replication of HCV.[9][10]
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Yamada S, Ohira M, Horie H, Ando K, Takayasu H, Suzuki Y, Sugano S, Hirata T, Goto T, Matsunaga T, Hiyama E, Hayashi Y, Ando H, Suita S, Kaneko M, Sasaki F, Hashizume K, Ohnuma N, Nakagawara A (2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene. 23 (35): 5901–11.
doi:
10.1038/sj.onc.1207782.
PMID15221005.
S2CID3114318.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007).
"Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89.
doi:
10.1038/msb4100134.
PMC1847948.
PMID17353931.
The human ADI1gene encodes the
enzyme1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase.[4][5][6]
Function
The enzyme belongs to the aci-reductone
dioxygenase family of metal-binding enzymes, which are involved in
methionine salvage. This enzyme may regulate
mRNA processing in the
nucleus, and may carry out different functions depending on its localization.
ADI1 is capable for supporting
hepatitis C virus replication in an otherwise non-permissive cell line.[7] Mouse hepatoma cells coexpressing human
CD81 and ADI1/Sip-L supported HCV infection and replication.[8] Human ADI1//Sip-L over-expression in 293 cells enhances cell entry but not replication of HCV.[9][10]
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Yamada S, Ohira M, Horie H, Ando K, Takayasu H, Suzuki Y, Sugano S, Hirata T, Goto T, Matsunaga T, Hiyama E, Hayashi Y, Ando H, Suita S, Kaneko M, Sasaki F, Hashizume K, Ohnuma N, Nakagawara A (2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene. 23 (35): 5901–11.
doi:
10.1038/sj.onc.1207782.
PMID15221005.
S2CID3114318.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007).
"Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89.
doi:
10.1038/msb4100134.
PMC1847948.
PMID17353931.