ACSS2, ACAS2, ACS, ACSA, dJ1161H23.1, acyl-CoA synthetase short chain family member 2, Acetyl-Coenzyme A Synthetase 2, Acetyl-Coenzyme A Synthetase, Cytoplasmic, ACECS1, ACECS
Acyl-coenzyme A synthetase short-chain family member 2 is an
enzyme that in
humans is encoded by the ACSS2gene.[5][6]
Function
This gene encodes a
cytosolicenzyme that catalyzes the activation of
acetate for use in
lipid synthesis and
energy generation. The protein acts as a
monomer and produces
acetyl-
CoA from acetate in a reaction that requires
ATP. It is also essential for the production of Crotonyl-CoA which activates its target genes by crotonylation of histone tails. Expression of this gene is regulated by
sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of
cholesterol and
unsaturatedfatty acids. Two transcript variants encoding different
isoforms have been found for this gene.[6]
Metabolic production of acetyl-CoA is linked to histone acetylation and gene regulation. In mouse neurons, Mews et al.[7] identified a major role for the ACSS2 pathway to regulate histone acetylation and neuronal gene expression. Histone acetylation in mature neurons is associated strongly with memory formation. Chromatin becomes acetylated in specific regions of the brain, such as the hippocampus, in response to neuronal activity or behavioral training in rodent.[8] Such acetylation correlates with the increased expression of a set of 'immediate early' genes,[9] which encode proteins that broadly mediate changes in the strength of connections between neurons, therefore facilitating memory consolidation.[10] In the mouse hippocampus, ACSS2 binds directly to immediate early genes to 'fuel' local histone acetylation and, in turn, their induction for long-term spatial memory.
^Schmitt M, Matthies H (1979). "[Biochemical studies on histones of the central nervous system. III. Incorporation of [14C]-acetate into the histones of different rat brain regions during a learning experiment]". Acta Biologica et Medica Germanica. 38 (4): 683–9.
PMID525146.
ACSS2, ACAS2, ACS, ACSA, dJ1161H23.1, acyl-CoA synthetase short chain family member 2, Acetyl-Coenzyme A Synthetase 2, Acetyl-Coenzyme A Synthetase, Cytoplasmic, ACECS1, ACECS
Acyl-coenzyme A synthetase short-chain family member 2 is an
enzyme that in
humans is encoded by the ACSS2gene.[5][6]
Function
This gene encodes a
cytosolicenzyme that catalyzes the activation of
acetate for use in
lipid synthesis and
energy generation. The protein acts as a
monomer and produces
acetyl-
CoA from acetate in a reaction that requires
ATP. It is also essential for the production of Crotonyl-CoA which activates its target genes by crotonylation of histone tails. Expression of this gene is regulated by
sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of
cholesterol and
unsaturatedfatty acids. Two transcript variants encoding different
isoforms have been found for this gene.[6]
Metabolic production of acetyl-CoA is linked to histone acetylation and gene regulation. In mouse neurons, Mews et al.[7] identified a major role for the ACSS2 pathway to regulate histone acetylation and neuronal gene expression. Histone acetylation in mature neurons is associated strongly with memory formation. Chromatin becomes acetylated in specific regions of the brain, such as the hippocampus, in response to neuronal activity or behavioral training in rodent.[8] Such acetylation correlates with the increased expression of a set of 'immediate early' genes,[9] which encode proteins that broadly mediate changes in the strength of connections between neurons, therefore facilitating memory consolidation.[10] In the mouse hippocampus, ACSS2 binds directly to immediate early genes to 'fuel' local histone acetylation and, in turn, their induction for long-term spatial memory.
^Schmitt M, Matthies H (1979). "[Biochemical studies on histones of the central nervous system. III. Incorporation of [14C]-acetate into the histones of different rat brain regions during a learning experiment]". Acta Biologica et Medica Germanica. 38 (4): 683–9.
PMID525146.