This gene encodes a
testis-specific, differentiation
antigen,
acrosomalvesicle protein 1, that arises within the acrosomal vesicle during
spermatogenesis, and is associated with the acrosomal
membranes and matrix of mature sperm. This gene consists of 4
exons and its alternative splicing generates multiple distinct transcripts, which encode protein
isoforms ranging from 81 to 265
amino acids. The longest transcript is the most abundant, comprising 53-72% of the total acrosomal vesicle protein 1 messages; the second largest transcript comprises 15-32%; the third and the fourth largest transcripts account for 3.4-8.3% and 8.7-12.5%, respectively; and the remaining transcripts combined account for < 1% of the total acrosomal vesicle protein 1 message. It is suggested that phenomena of cryptic splicing and
exon skipping occur within this gene. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration, and it is a potential contraceptive
vaccineimmunogen for humans.[7]
^Golden WL, von Kap-Herr C, Kurth B, Wright RM, Flickinger CJ, Eddy R, Shows T, Herr JC (Feb 1994). "Refinement of the localization of the gene for human intraacrosomal protein SP-10 (ACRV1) to the junction of bands q23→q24 of chromosome 11 by nonisotopic in situ hybridization". Genomics. 18 (2): 446–9.
doi:
10.1006/geno.1993.1496.
PMID8288254.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Reddi PP, Shore AN, Acharya KK, Herr JC (2002). "Transcriptional regulation of spermiogenesis: insights from the study of the gene encoding the acrosomal protein SP-10". J. Reprod. Immunol. 53 (1–2): 25–36.
doi:
10.1016/S0165-0378(01)00104-8.
PMID11730901.
This gene encodes a
testis-specific, differentiation
antigen,
acrosomalvesicle protein 1, that arises within the acrosomal vesicle during
spermatogenesis, and is associated with the acrosomal
membranes and matrix of mature sperm. This gene consists of 4
exons and its alternative splicing generates multiple distinct transcripts, which encode protein
isoforms ranging from 81 to 265
amino acids. The longest transcript is the most abundant, comprising 53-72% of the total acrosomal vesicle protein 1 messages; the second largest transcript comprises 15-32%; the third and the fourth largest transcripts account for 3.4-8.3% and 8.7-12.5%, respectively; and the remaining transcripts combined account for < 1% of the total acrosomal vesicle protein 1 message. It is suggested that phenomena of cryptic splicing and
exon skipping occur within this gene. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration, and it is a potential contraceptive
vaccineimmunogen for humans.[7]
^Golden WL, von Kap-Herr C, Kurth B, Wright RM, Flickinger CJ, Eddy R, Shows T, Herr JC (Feb 1994). "Refinement of the localization of the gene for human intraacrosomal protein SP-10 (ACRV1) to the junction of bands q23→q24 of chromosome 11 by nonisotopic in situ hybridization". Genomics. 18 (2): 446–9.
doi:
10.1006/geno.1993.1496.
PMID8288254.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Reddi PP, Shore AN, Acharya KK, Herr JC (2002). "Transcriptional regulation of spermiogenesis: insights from the study of the gene encoding the acrosomal protein SP-10". J. Reprod. Immunol. 53 (1–2): 25–36.
doi:
10.1016/S0165-0378(01)00104-8.
PMID11730901.