From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Not to be confused with
ACE1 .
Alkaline ceramidase 1 also known as ACER1 is a
ceramidase enzyme which in humans is encoded by the ACER1
gene .
[5]
Function
ACER1 mediates
cellular differentiation by controlling the generation of
sphingosine (SPH) and
sphingosine-1-phosphate (S1P).
[5]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000167769 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000045019 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b Mao C, Xu R, Szulc ZM, Bielawski J, Becker KP, Bielawska A, Galadari SH, Hu W, Obeid LM (Aug 2003).
"Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides" . The Journal of Biological Chemistry . 278 (33): 31184–91.
doi :
10.1074/jbc.M303875200 .
PMID
12783875 .
External links
Further reading
Sun W, Xu R, Hu W, Jin J, Crellin HA, Bielawski J, Szulc ZM, Thiers BH, Obeid LM, Mao C (Feb 2008).
"Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes" . The Journal of Investigative Dermatology . 128 (2): 389–97.
doi :
10.1038/sj.jid.5701025 .
PMID
17713573 .
Toulza E, Mattiuzzo NR, Galliano MF, Jonca N, Dossat C, Jacob D, de Daruvar A, Wincker P, Serre G, Guerrin M (2007).
"Large-scale identification of human genes implicated in epidermal barrier function" . Genome Biology . 8 (6): R107.
doi :
10.1186/gb-2007-8-6-r107 .
PMC
2394760 .
PMID
17562024 .
Ito M, Okino N, Tani M, Mitsutake S, Mori K (Mar 2002). "[Molecular evolution of neutral ceramidase: signalling molecule and virulence factor]". Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme . 47 (4 Suppl): 455–62.
PMID
11915342 .
Houben E, Holleran WM, Yaginuma T, Mao C, Obeid LM, Rogiers V, Takagi Y, Elias PM, Uchida Y (May 2006).
"Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis" . Journal of Lipid Research . 47 (5): 1063–70.
doi :
10.1194/jlr.M600001-JLR200 .
PMID
16477081 .