ATP-binding cassette, sub-family A (ABC1), member 5 is a
protein that in humans is encoded by the ABCA5
gene.[5]
Function
The
membrane-associated protein encoded by this gene is a member of the superfamily of
ATP-binding cassette (ABC) transporters. ABC proteins transport various molecule across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular
eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known.
Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008].
Petry F, Kotthaus A, Hirsch-Ernst KI (2003). "Cloning of human and rat ABCA5/Abca5 and detection of a human splice variant". Biochemical and Biophysical Research Communications. 300 (2): 343–50.
doi:
10.1016/s0006-291x(02)02827-9.
PMID12504089.
ATP-binding cassette, sub-family A (ABC1), member 5 is a
protein that in humans is encoded by the ABCA5
gene.[5]
Function
The
membrane-associated protein encoded by this gene is a member of the superfamily of
ATP-binding cassette (ABC) transporters. ABC proteins transport various molecule across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular
eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known.
Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008].
Petry F, Kotthaus A, Hirsch-Ernst KI (2003). "Cloning of human and rat ABCA5/Abca5 and detection of a human splice variant". Biochemical and Biophysical Research Communications. 300 (2): 343–50.
doi:
10.1016/s0006-291x(02)02827-9.
PMID12504089.