Adaptor-associated protein kinase 1 also known as AP2-associated protein kinase 1 is an
enzyme that in humans is encoded by the AAK1gene[5][6][7] and is involved in
clathrin mediated endocytosis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[7]
Function
Adaptor-related protein complex 2 (
AP-2 complexes) functions during receptor-mediated
endocytosis to trigger
clathrin assembly, interact with membrane-bound receptors, and recruit endocytic accessory factors. This gene encodes a member of the SNF1 subfamily of
Ser/Thr protein kinases. The protein interacts with and
phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent
receptor endocytosis. Its kinase activity is stimulated by clathrin.[7]
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". Journal of Proteome Research. 4 (4): 1339–46.
doi:
10.1021/pr050048h.
PMID16083285.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92.
doi:
10.1038/nbt1240.
PMID16964243.
S2CID14294292.
Adaptor-associated protein kinase 1 also known as AP2-associated protein kinase 1 is an
enzyme that in humans is encoded by the AAK1gene[5][6][7] and is involved in
clathrin mediated endocytosis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[7]
Function
Adaptor-related protein complex 2 (
AP-2 complexes) functions during receptor-mediated
endocytosis to trigger
clathrin assembly, interact with membrane-bound receptors, and recruit endocytic accessory factors. This gene encodes a member of the SNF1 subfamily of
Ser/Thr protein kinases. The protein interacts with and
phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent
receptor endocytosis. Its kinase activity is stimulated by clathrin.[7]
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". Journal of Proteome Research. 4 (4): 1339–46.
doi:
10.1021/pr050048h.
PMID16083285.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92.
doi:
10.1038/nbt1240.
PMID16964243.
S2CID14294292.