Names | |
---|---|
Preferred IUPAC name
3-Aminobenzamide | |
Other names
| |
Identifiers | |
3D model (
JSmol)
|
|
ChEBI | |
ChemSpider | |
ECHA InfoCard | 100.020.534 |
EC Number |
|
PubChem
CID
|
|
UNII | |
CompTox Dashboard (
EPA)
|
|
| |
| |
Properties | |
C7H8N2O | |
Molar mass | 136.154 g·mol−1 |
Appearance | Off-white powder |
Density | 1.233g/cm3 |
Melting point | 115 to 116 °C (239 to 241 °F; 388 to 389 K) |
Boiling point | 329 °C (624 °F; 602 K) |
log P | 0.33 |
Hazards | |
GHS labelling: | |
Danger | |
H302, H315, H319, H335 | |
P338, P351 | |
NFPA 704 (fire diamond) | |
Lethal dose or concentration (LD, LC): | |
LD50 (
median dose)
|
1000mg/kg (oral, bird) |
Safety data sheet (SDS) | Sigma-Aldrich |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
3-Aminobenzamide is a benzamide. It is an off-white powder and has the chemical formula C7H8N2O.
3-Aminobenzamide can be prepared through the reduction of 3-nitrobenzamide by catalytic hydrogenation. [1]
3-Aminobenzamide is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme responsible for DNA repair, transcription control, and programmed cell death. [1] When PARP is activated it rapidly uses up stores of nicotinamide adenine dinucleotide (NAD+) in the cell as it performs DNA repair. Low levels of NAD+ deplete the amount of ATP found in the cell which can lead to cell death. [2] The structure of 3-aminobenzamide is similar to that of NAD+ so it binds to PARP and prevents it from using up NAD+. PARP is often a target of cancer therapy and so 3-aminobenzamide could potentially be used as an anticancer drug. [3]
Names | |
---|---|
Preferred IUPAC name
3-Aminobenzamide | |
Other names
| |
Identifiers | |
3D model (
JSmol)
|
|
ChEBI | |
ChemSpider | |
ECHA InfoCard | 100.020.534 |
EC Number |
|
PubChem
CID
|
|
UNII | |
CompTox Dashboard (
EPA)
|
|
| |
| |
Properties | |
C7H8N2O | |
Molar mass | 136.154 g·mol−1 |
Appearance | Off-white powder |
Density | 1.233g/cm3 |
Melting point | 115 to 116 °C (239 to 241 °F; 388 to 389 K) |
Boiling point | 329 °C (624 °F; 602 K) |
log P | 0.33 |
Hazards | |
GHS labelling: | |
Danger | |
H302, H315, H319, H335 | |
P338, P351 | |
NFPA 704 (fire diamond) | |
Lethal dose or concentration (LD, LC): | |
LD50 (
median dose)
|
1000mg/kg (oral, bird) |
Safety data sheet (SDS) | Sigma-Aldrich |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
3-Aminobenzamide is a benzamide. It is an off-white powder and has the chemical formula C7H8N2O.
3-Aminobenzamide can be prepared through the reduction of 3-nitrobenzamide by catalytic hydrogenation. [1]
3-Aminobenzamide is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme responsible for DNA repair, transcription control, and programmed cell death. [1] When PARP is activated it rapidly uses up stores of nicotinamide adenine dinucleotide (NAD+) in the cell as it performs DNA repair. Low levels of NAD+ deplete the amount of ATP found in the cell which can lead to cell death. [2] The structure of 3-aminobenzamide is similar to that of NAD+ so it binds to PARP and prevents it from using up NAD+. PARP is often a target of cancer therapy and so 3-aminobenzamide could potentially be used as an anticancer drug. [3]