Names | |
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IUPAC name
2-Amino-3-[4-(4-hydroxyphenoxy)-3,5-diiodophenyl]propanoic acid
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Identifiers | |
3D model (
JSmol)
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ChemSpider | |
MeSH | 3,5-diiodothyronine |
PubChem
CID
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UNII | |
CompTox Dashboard (
EPA)
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Properties | |
C15H13I2NO4 | |
Molar mass | 525.081 g·mol−1 |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
3,5-Diiodothyronine (3,5-T2) is an active thyroid hormone within the class of iodothyronines. It has two iodine atoms at positions 3 and 5 of its inner ring.
3,5-T2 is an active thyroid hormone. It stimulates the TR-beta receptor for thyroid hormones and thus increases energy expenditure. [1] [2] It has agonistic (thyromimetic) effects at myocardial tissue and pituitary, which results in 3,5-T2 suppressing TSH release. [3] [4] 3,5-T2 is an allosteric regulator of the cytochrome c oxidase, the complex IV of the electron transport chain. It increases its activity by preventing the interaction of adenosine triphosphate (ATP) as an allosteric inhibitor. [5]
In nonthyroidal illness syndrome 3,5-T2 concentrations are increased. [6] [7] [8] [9] This could explain why patients with low T3 syndrome don't benefit from substitution therapy with thyroid hormones. [7]
Names | |
---|---|
IUPAC name
2-Amino-3-[4-(4-hydroxyphenoxy)-3,5-diiodophenyl]propanoic acid
| |
Identifiers | |
3D model (
JSmol)
|
|
ChemSpider | |
MeSH | 3,5-diiodothyronine |
PubChem
CID
|
|
UNII | |
CompTox Dashboard (
EPA)
|
|
| |
| |
Properties | |
C15H13I2NO4 | |
Molar mass | 525.081 g·mol−1 |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
3,5-Diiodothyronine (3,5-T2) is an active thyroid hormone within the class of iodothyronines. It has two iodine atoms at positions 3 and 5 of its inner ring.
3,5-T2 is an active thyroid hormone. It stimulates the TR-beta receptor for thyroid hormones and thus increases energy expenditure. [1] [2] It has agonistic (thyromimetic) effects at myocardial tissue and pituitary, which results in 3,5-T2 suppressing TSH release. [3] [4] 3,5-T2 is an allosteric regulator of the cytochrome c oxidase, the complex IV of the electron transport chain. It increases its activity by preventing the interaction of adenosine triphosphate (ATP) as an allosteric inhibitor. [5]
In nonthyroidal illness syndrome 3,5-T2 concentrations are increased. [6] [7] [8] [9] This could explain why patients with low T3 syndrome don't benefit from substitution therapy with thyroid hormones. [7]