In molecular biology 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (OHCU decarboxylase)
EC4.1.1.n1 is an
enzyme involved in
purinecatabolism. It
catalyses the
decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) into S(+)-allantoin.[1][2] It is the third step of the conversion of uric acid (a purine derivative) to allantoin. Step one is catalysed by
urate oxidase and step two is catalysed by
hydroxyisourate hydrolase.[3][4]
References
^Ramazzina I, Folli C, Secchi A, Berni R, Percudani R (March 2006). "Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes". Nat. Chem. Biol. 2 (3): 144–8.
doi:
10.1038/nchembio768.
PMID16462750.
S2CID13441301.
In molecular biology 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (OHCU decarboxylase)
EC4.1.1.n1 is an
enzyme involved in
purinecatabolism. It
catalyses the
decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) into S(+)-allantoin.[1][2] It is the third step of the conversion of uric acid (a purine derivative) to allantoin. Step one is catalysed by
urate oxidase and step two is catalysed by
hydroxyisourate hydrolase.[3][4]
References
^Ramazzina I, Folli C, Secchi A, Berni R, Percudani R (March 2006). "Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes". Nat. Chem. Biol. 2 (3): 144–8.
doi:
10.1038/nchembio768.
PMID16462750.
S2CID13441301.