Names | |
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IUPAC name
(1R)-1,4-Anhydro-1-[(2,5-diamino-6-oxo-1,6-dihydropyrimidin-4-yl)amino]-D-ribitol 5-(dihydrogen phosphate)
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Systematic IUPAC name
{(2R,3S,4R,5R)-5-[(2,5-Diamino-6-oxo-1,6-dihydropyrimidin-4-yl)amino]-3,4-dihydroxyoxolan-2-yl}methyl dihydrogen phosphate | |
Other names
2,5-Diamino-6-ribofuranosylamino-4(3H)-pyrimidinone monophosphate; N-(2,5-Diamino-6-hydroxypyrimidin-4-yl)-5-O-phosphono-β-D-ribofuranosylamine
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Identifiers | |
3D model (
JSmol)
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ChEBI |
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ChemSpider | |
KEGG | |
PubChem
CID
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CompTox Dashboard (
EPA)
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Properties | |
C9H16N5O8P | |
Molar mass | 353.23 g/mol |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
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2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine is a metabolite in the purine metabolism, formed by the hydrolysis of GTP by GTP cyclohydrolase II. [1] Alternatively two separate enzymes can carry out this reaction, initially GTP cyclohydrolase IIa hydrolyses the 8,9 bond to form 2-Amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one, [2] followed by de-formylation by 2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase. [3] 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine is deaminated by Diaminohydroxyphosphoribosylaminopyrimidine deaminase to form 5-amino-6-(5-phosphoribosylamino)uracil. [4]
Names | |
---|---|
IUPAC name
(1R)-1,4-Anhydro-1-[(2,5-diamino-6-oxo-1,6-dihydropyrimidin-4-yl)amino]-D-ribitol 5-(dihydrogen phosphate)
| |
Systematic IUPAC name
{(2R,3S,4R,5R)-5-[(2,5-Diamino-6-oxo-1,6-dihydropyrimidin-4-yl)amino]-3,4-dihydroxyoxolan-2-yl}methyl dihydrogen phosphate | |
Other names
2,5-Diamino-6-ribofuranosylamino-4(3H)-pyrimidinone monophosphate; N-(2,5-Diamino-6-hydroxypyrimidin-4-yl)-5-O-phosphono-β-D-ribofuranosylamine
| |
Identifiers | |
3D model (
JSmol)
|
|
ChEBI |
|
ChemSpider | |
KEGG | |
PubChem
CID
|
|
CompTox Dashboard (
EPA)
|
|
| |
| |
Properties | |
C9H16N5O8P | |
Molar mass | 353.23 g/mol |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine is a metabolite in the purine metabolism, formed by the hydrolysis of GTP by GTP cyclohydrolase II. [1] Alternatively two separate enzymes can carry out this reaction, initially GTP cyclohydrolase IIa hydrolyses the 8,9 bond to form 2-Amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one, [2] followed by de-formylation by 2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase. [3] 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine is deaminated by Diaminohydroxyphosphoribosylaminopyrimidine deaminase to form 5-amino-6-(5-phosphoribosylamino)uracil. [4]