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This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Laurelcarmichael25.
Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT ( talk) 12:14, 17 January 2022 (UTC)
I added a comment about Orfiril being a Valproic acid product (and forwarded the 'Orfiril' page to this), but I'm not sure whether it's a Sodium valproate, Divalproex Sodium or maybe something else so I just put it as a note in there. If someone knows what sort of Valproic acid it is, I think it should be put in the same paragraph as the description of it. njh
Shouldn't Depakote be added as a fomulation that contains valproic acid?
From wikipedia itself:
Valproate semisodium From Wikipedia, the free encyclopedia (Redirected from Depakote) Jump to: navigation, search Valproate semisodium (INN) or divalproex sodium (USAN) consists of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form. —The preceding unsigned comment was added by Jaerik ( talk • contribs) 00:10, 22 May 2006 UTC.
Surely the brand names listed under formulations needs a bit of expansion? How can you tell if it's not just one formulation made in different places with different names for different markets? — Preceding unsigned comment added by 217.155.82.154 ( talk) 11:05, April 11, 2007 (UTC)
heres the link if someone wants to put the proper tag in http://www.medpagetoday.com/Pediatrics/GeneralPediatrics/tb/5386
Do companies delete web pages because they still using 1980's 10MB drives? https://web.archive.org/web/20070526011514/http://www.medpagetoday.com/Pediatrics/GeneralPediatrics/tb/5386 Moms who take it can make less smart babies
and the info
Primary source: American Academy of Neurology 2007 Annual Meeting
Source reference: Meador KJ et al. "Cognitive Outcomes at 2 Years Old in Children of Women with Epilepsy Differ as Function of In Utero Antiepileptic Drug." Abstract S45.003, presented May 3. — Preceding unsigned comment added by 74.98.9.225 ( talk) 22:33, May 13, 2007 (UTC)
The article states: "Valproic acid also causes hyperammonemia." The article on Lithium pharmacology states: "An increasing number of scientists have come to the conclusion that the excitatory neurotransmitter glutamate is the key factor in understanding how lithium works" (citation needed), but without specifying in what way: does it potentiate it or antagonize it? Given that one of the main actions of glutamine is to reduce ammonia in the blood and brain, is there a significant connection here? The two are often prescribed together. If antagonism is the effect, would glutamine supplementation be appropriate when taking these two drugs together? Carusus 10:31, 24 September 2007 (UTC)
Valproic acid, as I have read causes Hepatic toxicity. But I haven't really read anything about whether or not it is suitable for child use. Is it ok for a 3 or 4 year old child to use Valproic acid for treatment of Epilepsy? —Preceding unsigned comment added by 194.170.95.210 ( talk) 04:21, 16 April 2008 (UTC)
In this and other Wikipedia medical articles, there should be more attention paid to clarifying what medical terms mean in ordinary English to maximize the usefulness of an article. This is not a medical text, this is a general Web site. Please translate complex technical terms in addition to providing links to other articles.
Why? Azu Mao ( talk) 18:45, 6 August 2010 (UTC)
I have added Valparin, as one of the commectial names. When I use Valparin in the search window, it does bring up this same page. Please check for veracity. Several documents also mention that one of the commercial names of Valproic acid is Valparin. -- C.R.Selvakumar ( talk) 20:05, 29 April 2011 (UTC)
I checked the "Cancer" section and it turned out to be basically plagiarized from http://www.news-medical.net/health/Valproic-Acid-Uses.aspx which doesn't seem to be a WP:RS. There are links to original studies (some of which are dead links), but they're cell culture and other preliminary research that would violate WP:MEDMOS, and at best it's WP:OR.
I didn't check out the entire "Investigational" section but it also seems to be similarly unreliable.
One of the problems with valproic acid is that manufacturers are (illegally) promoting it in the US for all kinds of off-label indications. There are lots of unsupported claims going around.
I personally think the molecular biology stuff is very interesting, as biology, but any mention should make it clear that these are not clinical indications. -- Nbauman ( talk) 15:23, 8 May 2012 (UTC)
The section that explains how organic acids are named doesn't belong in this article — Preceding unsigned comment added by 184.47.48.24 ( talk) 20:39, 8 August 2012 (UTC)
VPA and valproate seem to be used here as clinically equivalent. Are they ? - Rod57 ( talk) 12:21, 24 March 2013 (UTC) vpa is an abbreviation for valproic acid while valproate is the ion form of the drug (as is the case in all of chemistry naming schemes). they are functionally interchangeable. sodium divalproex and valproic acid are both absorbed as valproate in the gastrointestinal tract, where divalproex is cleaved in half to yield 2 valproates. — Preceding unsigned comment added by 159.238.36.19 ( talk) 21:25, 16 June 2014 (UTC)
Article states valproate can be used for treatment of depression. This requires reference(s). — Preceding unsigned comment added by 132.234.251.230 ( talk) 22:43, 1 September 2013 (UTC)
I don't have time right now but I discovered the following article about an interesting research result about valproic acid. Maybe someone can add this?
http://www.dailymail.co.uk/sciencetech/article-2531276/Bad-singer-Theres-DRUG-Brain-altering-compound-help-cure-tone-deafness.html — Preceding unsigned comment added by 82.176.83.178 ( talk) 00:23, 14 January 2014 (UTC)
References:
{{
cite journal}}
: CS1 maint: multiple names: authors list (
link) CS1 maint: unflagged free DOI (
link)
Most of these "miracle" neuropills just alter metabolic balance plus this one burns into an alkene.. Check pregabalin for these same conditions maybe? This medicine and tricyclic antidepressants and neuroleptics just scream for cancer. I think there is much smarter ways to save energy.. -- Slowpoke21837240 ( talk) 14:05, 23 January 2015 (UTC)
We basically have three article dealing with what is basically the same drug: Valproic acid, Sodium valproate and Valproate semisodium. I suggest that we merge them all to this Valproate page (which is currently a redirect), since "valproate" is more commonly used than "Valproic acid", both in standard Google ( [1] compared to [2]) and Google Scholar ( [3] compared to [4]). Also, the fact that it is an acid is not important in reality, so the simpler name is better. A merge would avail for finding all relevant characteristics in one place, without risking to miss something by ending up in the wrong one of those three articles. I don't see any text in any of these articles specifically mentioning any difference between the three formulations, and after the merge we should have a section dealing with that topic (if we find anything). Official listings of adverse effects may practically vary somewhat, but we already have e.g. List of adverse effects of valproate semisodium as a separate page. We can discuss later whether to try to merge lists of adverse effects to into one as well, like first listing those that are common to all formulations and then detailing differences. Mikael Häggström ( talk) 13:29, 6 June 2015 (UTC)
See this ANI request (permanent link) by User:Mikael Häggström. Valproate was only a redirect, so the name was available for a merged article. As stated in the above section, the idea is to move Valproic acid to Valproate, preserving the target talk page in some way, and then merging in Sodium valproate and Valproate semisodium. I've done the move to Valproate, so the history of Valproic acid has been preserved. The people who've been working on this should go ahead and merge in any useful information from Sodium valproate and Valproate semisodium. Those histories can only be captured indirectly; see WP:Copying within Wikipedia for some options. The original content of Talk:Valproate has been saved here by merging the text in. I've replaced Sodium valproate and Valproate semisodium with redirects but the former content of those articles is still in the history. I left the original talk pages at Talk:Sodium valproate and Talk:Valproate semisodium undisturbed. Probably they should also be changed to redirects after their content is preserved. Let me know if you have any questions. Thanks, EdJohnston ( talk) 20:36, 14 June 2015 (UTC)
"details of use and efficacy. This is one of the most widely used anticonvulsants, but we have only 2 sentences describing its use and efficacy, vs. scores describing AEs, contraindications, interactions, and brand names used in developing markets. We're all very clear on what the problems are with the drug, and what its called in Bhutan, but a little sketchy on how and why it is used" Doc James ( talk · contribs · email) 13:12, 23 October 2015 (UTC)
Took the liberty to revise and reorganize the article. Revisions included updating and re-organizing the drug indications, drug interactions, general adverse effects, adverse reactions in pregnancy and the overdose sections. Also cleaned up the grammar and syntax of the article to keep it more concise and improve word flow. Lastly added a new section for adverse effects in the elderly. Laurelcarmichael25 ( talk) 19:21, 5 November 2015 (UTC)
1. Does the article provide a neutral point of view? Yes. The article is written in an objective manner and it doesn’t have opinions or thoughts of the authors.
2. Are the points included verifiable with cited published material? See below for recommendations.
3. What recommendations can you provide your colleague for improvement of their draft?
The adverse effects list gives % incidence but does not state what doses or conditions being treated these relate to. What dose ranges are used for different indications ? At what dosage are the pregnancy effects reported (since it advises to reduce dosage in pregnancy) ? - Rod57 ( talk) 15:35, 9 March 2016 (UTC)
Kudos to @ Doc James:. The move from this version to this version was sheer brilliance. In retrospect I am embarrassed that I did not think of it myself. Like all genius moves it is "obvious in retrospect." I look forward to emulating the move. The heart of it is that beyond straightening out the ontologic error (which is the first level of improvement, which I was analytically focused on), one can mention the various forms of something, up front, in such words ("various forms" etc), without explaining at that spot how they differ from each other. Which certainly comes later (versus not at all). Thus goes the next level of improvement, a pedagogical one. Thanks again. Quercus solaris ( talk) 03:13, 9 August 2016 (UTC)
Seppi333 ( Insert 2¢) 19:28, 30 July 2017 (UTC)
The entry for valproate should include a section on it's impacts on folate, since it is a known folic acid inhibitor. See Wikipedia entry on folate: /info/en/?search=Folate#Drugs_that_interfere_with_folate_reactions
I elaborated the name of the "pregnancy" section under "adverse effects" to "pregnancy, IQ, and autism", perhaps this section can be better broken up into 2-3 sections (very open to suggestions). In any case, I added a citation as well, a review of literature going back more than a decade concerning autism models in rodents for perinatal induction and some relevance for medicated adults themselves (worsening negative symptoms for folks already on-spectrum). It's a bit strange that this stuff isn't already here as pretty much every serious psychiatrist, neurologist, or neuropsychologist that I have met, other than myself seems to be aware of this relationship. I'm especially surprised with this rating -> "WikiProject Autism|class=B|importance=Low"; I will lobby to increase the rating. Thoughts? I've signed my edit on the page the same as well -> talonx 78.54.38.80 ( talk) 15:29, 25 October 2020 (UTC)
But no term "Epilex" in "Valproate". Effete link. 2600:1700:9AAE:7010:4D9D:F6FC:D945:9BB5 ( talk) 17:09, 31 July 2023 (UTC)
This is the
talk page for discussing improvements to the
Valproate article. This is not a forum for general discussion of the article's subject. |
Article policies
|
Find medical sources: Source guidelines · PubMed · Cochrane · DOAJ · Gale · OpenMD · ScienceDirect · Springer · Trip · Wiley · TWL |
This article is rated B-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: |
|||||||||||||||||||||||||||||||||||||||||||||||
|
Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Valproate.
|
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Laurelcarmichael25.
Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT ( talk) 12:14, 17 January 2022 (UTC)
I added a comment about Orfiril being a Valproic acid product (and forwarded the 'Orfiril' page to this), but I'm not sure whether it's a Sodium valproate, Divalproex Sodium or maybe something else so I just put it as a note in there. If someone knows what sort of Valproic acid it is, I think it should be put in the same paragraph as the description of it. njh
Shouldn't Depakote be added as a fomulation that contains valproic acid?
From wikipedia itself:
Valproate semisodium From Wikipedia, the free encyclopedia (Redirected from Depakote) Jump to: navigation, search Valproate semisodium (INN) or divalproex sodium (USAN) consists of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form. —The preceding unsigned comment was added by Jaerik ( talk • contribs) 00:10, 22 May 2006 UTC.
Surely the brand names listed under formulations needs a bit of expansion? How can you tell if it's not just one formulation made in different places with different names for different markets? — Preceding unsigned comment added by 217.155.82.154 ( talk) 11:05, April 11, 2007 (UTC)
heres the link if someone wants to put the proper tag in http://www.medpagetoday.com/Pediatrics/GeneralPediatrics/tb/5386
Do companies delete web pages because they still using 1980's 10MB drives? https://web.archive.org/web/20070526011514/http://www.medpagetoday.com/Pediatrics/GeneralPediatrics/tb/5386 Moms who take it can make less smart babies
and the info
Primary source: American Academy of Neurology 2007 Annual Meeting
Source reference: Meador KJ et al. "Cognitive Outcomes at 2 Years Old in Children of Women with Epilepsy Differ as Function of In Utero Antiepileptic Drug." Abstract S45.003, presented May 3. — Preceding unsigned comment added by 74.98.9.225 ( talk) 22:33, May 13, 2007 (UTC)
The article states: "Valproic acid also causes hyperammonemia." The article on Lithium pharmacology states: "An increasing number of scientists have come to the conclusion that the excitatory neurotransmitter glutamate is the key factor in understanding how lithium works" (citation needed), but without specifying in what way: does it potentiate it or antagonize it? Given that one of the main actions of glutamine is to reduce ammonia in the blood and brain, is there a significant connection here? The two are often prescribed together. If antagonism is the effect, would glutamine supplementation be appropriate when taking these two drugs together? Carusus 10:31, 24 September 2007 (UTC)
Valproic acid, as I have read causes Hepatic toxicity. But I haven't really read anything about whether or not it is suitable for child use. Is it ok for a 3 or 4 year old child to use Valproic acid for treatment of Epilepsy? —Preceding unsigned comment added by 194.170.95.210 ( talk) 04:21, 16 April 2008 (UTC)
In this and other Wikipedia medical articles, there should be more attention paid to clarifying what medical terms mean in ordinary English to maximize the usefulness of an article. This is not a medical text, this is a general Web site. Please translate complex technical terms in addition to providing links to other articles.
Why? Azu Mao ( talk) 18:45, 6 August 2010 (UTC)
I have added Valparin, as one of the commectial names. When I use Valparin in the search window, it does bring up this same page. Please check for veracity. Several documents also mention that one of the commercial names of Valproic acid is Valparin. -- C.R.Selvakumar ( talk) 20:05, 29 April 2011 (UTC)
I checked the "Cancer" section and it turned out to be basically plagiarized from http://www.news-medical.net/health/Valproic-Acid-Uses.aspx which doesn't seem to be a WP:RS. There are links to original studies (some of which are dead links), but they're cell culture and other preliminary research that would violate WP:MEDMOS, and at best it's WP:OR.
I didn't check out the entire "Investigational" section but it also seems to be similarly unreliable.
One of the problems with valproic acid is that manufacturers are (illegally) promoting it in the US for all kinds of off-label indications. There are lots of unsupported claims going around.
I personally think the molecular biology stuff is very interesting, as biology, but any mention should make it clear that these are not clinical indications. -- Nbauman ( talk) 15:23, 8 May 2012 (UTC)
The section that explains how organic acids are named doesn't belong in this article — Preceding unsigned comment added by 184.47.48.24 ( talk) 20:39, 8 August 2012 (UTC)
VPA and valproate seem to be used here as clinically equivalent. Are they ? - Rod57 ( talk) 12:21, 24 March 2013 (UTC) vpa is an abbreviation for valproic acid while valproate is the ion form of the drug (as is the case in all of chemistry naming schemes). they are functionally interchangeable. sodium divalproex and valproic acid are both absorbed as valproate in the gastrointestinal tract, where divalproex is cleaved in half to yield 2 valproates. — Preceding unsigned comment added by 159.238.36.19 ( talk) 21:25, 16 June 2014 (UTC)
Article states valproate can be used for treatment of depression. This requires reference(s). — Preceding unsigned comment added by 132.234.251.230 ( talk) 22:43, 1 September 2013 (UTC)
I don't have time right now but I discovered the following article about an interesting research result about valproic acid. Maybe someone can add this?
http://www.dailymail.co.uk/sciencetech/article-2531276/Bad-singer-Theres-DRUG-Brain-altering-compound-help-cure-tone-deafness.html — Preceding unsigned comment added by 82.176.83.178 ( talk) 00:23, 14 January 2014 (UTC)
References:
{{
cite journal}}
: CS1 maint: multiple names: authors list (
link) CS1 maint: unflagged free DOI (
link)
Most of these "miracle" neuropills just alter metabolic balance plus this one burns into an alkene.. Check pregabalin for these same conditions maybe? This medicine and tricyclic antidepressants and neuroleptics just scream for cancer. I think there is much smarter ways to save energy.. -- Slowpoke21837240 ( talk) 14:05, 23 January 2015 (UTC)
We basically have three article dealing with what is basically the same drug: Valproic acid, Sodium valproate and Valproate semisodium. I suggest that we merge them all to this Valproate page (which is currently a redirect), since "valproate" is more commonly used than "Valproic acid", both in standard Google ( [1] compared to [2]) and Google Scholar ( [3] compared to [4]). Also, the fact that it is an acid is not important in reality, so the simpler name is better. A merge would avail for finding all relevant characteristics in one place, without risking to miss something by ending up in the wrong one of those three articles. I don't see any text in any of these articles specifically mentioning any difference between the three formulations, and after the merge we should have a section dealing with that topic (if we find anything). Official listings of adverse effects may practically vary somewhat, but we already have e.g. List of adverse effects of valproate semisodium as a separate page. We can discuss later whether to try to merge lists of adverse effects to into one as well, like first listing those that are common to all formulations and then detailing differences. Mikael Häggström ( talk) 13:29, 6 June 2015 (UTC)
See this ANI request (permanent link) by User:Mikael Häggström. Valproate was only a redirect, so the name was available for a merged article. As stated in the above section, the idea is to move Valproic acid to Valproate, preserving the target talk page in some way, and then merging in Sodium valproate and Valproate semisodium. I've done the move to Valproate, so the history of Valproic acid has been preserved. The people who've been working on this should go ahead and merge in any useful information from Sodium valproate and Valproate semisodium. Those histories can only be captured indirectly; see WP:Copying within Wikipedia for some options. The original content of Talk:Valproate has been saved here by merging the text in. I've replaced Sodium valproate and Valproate semisodium with redirects but the former content of those articles is still in the history. I left the original talk pages at Talk:Sodium valproate and Talk:Valproate semisodium undisturbed. Probably they should also be changed to redirects after their content is preserved. Let me know if you have any questions. Thanks, EdJohnston ( talk) 20:36, 14 June 2015 (UTC)
"details of use and efficacy. This is one of the most widely used anticonvulsants, but we have only 2 sentences describing its use and efficacy, vs. scores describing AEs, contraindications, interactions, and brand names used in developing markets. We're all very clear on what the problems are with the drug, and what its called in Bhutan, but a little sketchy on how and why it is used" Doc James ( talk · contribs · email) 13:12, 23 October 2015 (UTC)
Took the liberty to revise and reorganize the article. Revisions included updating and re-organizing the drug indications, drug interactions, general adverse effects, adverse reactions in pregnancy and the overdose sections. Also cleaned up the grammar and syntax of the article to keep it more concise and improve word flow. Lastly added a new section for adverse effects in the elderly. Laurelcarmichael25 ( talk) 19:21, 5 November 2015 (UTC)
1. Does the article provide a neutral point of view? Yes. The article is written in an objective manner and it doesn’t have opinions or thoughts of the authors.
2. Are the points included verifiable with cited published material? See below for recommendations.
3. What recommendations can you provide your colleague for improvement of their draft?
The adverse effects list gives % incidence but does not state what doses or conditions being treated these relate to. What dose ranges are used for different indications ? At what dosage are the pregnancy effects reported (since it advises to reduce dosage in pregnancy) ? - Rod57 ( talk) 15:35, 9 March 2016 (UTC)
Kudos to @ Doc James:. The move from this version to this version was sheer brilliance. In retrospect I am embarrassed that I did not think of it myself. Like all genius moves it is "obvious in retrospect." I look forward to emulating the move. The heart of it is that beyond straightening out the ontologic error (which is the first level of improvement, which I was analytically focused on), one can mention the various forms of something, up front, in such words ("various forms" etc), without explaining at that spot how they differ from each other. Which certainly comes later (versus not at all). Thus goes the next level of improvement, a pedagogical one. Thanks again. Quercus solaris ( talk) 03:13, 9 August 2016 (UTC)
Seppi333 ( Insert 2¢) 19:28, 30 July 2017 (UTC)
The entry for valproate should include a section on it's impacts on folate, since it is a known folic acid inhibitor. See Wikipedia entry on folate: /info/en/?search=Folate#Drugs_that_interfere_with_folate_reactions
I elaborated the name of the "pregnancy" section under "adverse effects" to "pregnancy, IQ, and autism", perhaps this section can be better broken up into 2-3 sections (very open to suggestions). In any case, I added a citation as well, a review of literature going back more than a decade concerning autism models in rodents for perinatal induction and some relevance for medicated adults themselves (worsening negative symptoms for folks already on-spectrum). It's a bit strange that this stuff isn't already here as pretty much every serious psychiatrist, neurologist, or neuropsychologist that I have met, other than myself seems to be aware of this relationship. I'm especially surprised with this rating -> "WikiProject Autism|class=B|importance=Low"; I will lobby to increase the rating. Thoughts? I've signed my edit on the page the same as well -> talonx 78.54.38.80 ( talk) 15:29, 25 October 2020 (UTC)
But no term "Epilex" in "Valproate". Effete link. 2600:1700:9AAE:7010:4D9D:F6FC:D945:9BB5 ( talk) 17:09, 31 July 2023 (UTC)