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As per my understanding of chemistry, as suggested by the discernation of a derivative and structural analogue; would make that of a medication with a similar structure to gabapentinoids the primary criterion...not whether or not they are in terms of pharmacodynamics similar, in terms of mechanism of action. Sic, excluding phenibut from being that of a gabapentinoid; as the only similar feature is the inclusion of the gabba-aminobutryic acid amino group; however, lacks the phenyl group or aromatic heterocyclic compound that GABA reacted with phenylacetic acid is derived from...thus; the primary precursor is GABA and beta-phenyl-gamma-aminobutyric acid is thus, the derivative...reiterating that it is indeed that of a derivative, rather, than that of a gabapentinoid. It could be argued because both phenibut and pregabalin share some similar qualities in terms of mechanism of action and that of the GABA molecule that it could be both...however, which would be the primary quality? The pharmacologist and chemist could argue all day...nature versus nurture?

This is due to the ambiguity of the recent distinction between that of a derivative and structural analog in chemistry and also pharmacology; and was thus coined separate identifying terminologies as a result. Structural analogues are drugs similar in structure, making them just that: analogues; whilst, drugs only similar in mechanism of action would be that of derivatives; derived from a similar compound or derived from a precursor compound by that of a chemical reaction, or thought to act similarly to another compound; i.e., the two separate terms opioid and opiate are used as an example, as an opioid is semi/fully synthetic and only a derivative in terms of sharing a similar mechanism of action per modulating the Mu-Opioid Receptor, to that of an opiate, which does the same, however, is natural to nature in the sense that it is derived from an alkaloid from p. Somniferum.

This is at least my understanding...

KR — Preceding unsigned comment added by 50.49.26.127 ( talk) 00:52, 28 January 2016 (UTC) reply