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I would like to propose splitting this article in two articles, one for the dominant form and one for the recessive form. The two forms are quite different from each other and I think it is probably confusing to describe them both in one article. -- WS 00:55, 21 December 2006 (UTC)
The page for the Dominant form of the disease is much more descriptive and complete than this page, and this page gives the impression that it is the only wikipedia page on the subject (I would not have found the page for the Dominant form without checking the discussion). I recomend either removing this page and directing users to a disambiguation page, or re-merging the Dominant and Recessive pages. Failing that, a recomendation to go to the Dominant page (or Recessive page) should be prominently placed, to help users find the information they want. Chris45215 ( talk) 02:18, 26 December 2008 (UTC)
Will work on this as time permits....
Good review article: http://www.nature.com/ki/journal/v76/n2/full/ki2009128a.html
Wawot1 ( talk) 14:28, 19 June 2011 (UTC)
I've changed the introduction around quite a bit - there really wasn't a general summary statement and it seems that the prior intro was a remnant of when this article was simply polycystic kidney disease, rather than autosomal dominant polycystic kidney disease. I added a statement about ARPKD being a distinct entity, but I don't think this is the place to say much about it - its own dedicated page is the appropriate venue for this info. I also removed the sentence:
because the two references behind this statement were the Zerres paper, which is about ARPKD, and the Dalgaard paper, which I don't have access to and which was written in the 1950's - a lot has changed since then. I'm a bit skeptical of this claim (a brief review of UpToDate and one or two other reviews didn't repeat a similar statement). Please, though, if anybody has a more recent reliable source, add it!
Wawot1 ( talk) 16:18, 19 June 2011 (UTC)
Somebody just made a radical change of meaning to a long-standing statement. I have no idea if it was an improvement. [1]
"Failure in flow-sensing signaling results in programmed cell death ( apoptosis) of these renal epithelial cells, producing the characteristic multiple cysts of PKD."
to
"Failure in flow-sensing signaling results in proliforation of these renal epithelial cells, producing the characteristic multiple cysts of PKD.
Reading the (free) source leaves me none the wiser. Someone who understands the topic should have a look. Anthonyhcole ( talk · contribs · email) 19:42, 16 January 2014 (UTC)
The article implies that tolvaptan isn't approved in the US, but it is. See the Aquaretic section. The phrase in question: "...the approval of the drug [tolvaptan] was either delayed by regulatory agencies or, as in case of the US, altogether denied." ― Biochemistry🙴❤ 14:24, 24 August 2018 (UTC)
This article is rated B-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: |
|||||||||||||||||
|
Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Autosomal dominant polycystic kidney disease.
|
I would like to propose splitting this article in two articles, one for the dominant form and one for the recessive form. The two forms are quite different from each other and I think it is probably confusing to describe them both in one article. -- WS 00:55, 21 December 2006 (UTC)
The page for the Dominant form of the disease is much more descriptive and complete than this page, and this page gives the impression that it is the only wikipedia page on the subject (I would not have found the page for the Dominant form without checking the discussion). I recomend either removing this page and directing users to a disambiguation page, or re-merging the Dominant and Recessive pages. Failing that, a recomendation to go to the Dominant page (or Recessive page) should be prominently placed, to help users find the information they want. Chris45215 ( talk) 02:18, 26 December 2008 (UTC)
Will work on this as time permits....
Good review article: http://www.nature.com/ki/journal/v76/n2/full/ki2009128a.html
Wawot1 ( talk) 14:28, 19 June 2011 (UTC)
I've changed the introduction around quite a bit - there really wasn't a general summary statement and it seems that the prior intro was a remnant of when this article was simply polycystic kidney disease, rather than autosomal dominant polycystic kidney disease. I added a statement about ARPKD being a distinct entity, but I don't think this is the place to say much about it - its own dedicated page is the appropriate venue for this info. I also removed the sentence:
because the two references behind this statement were the Zerres paper, which is about ARPKD, and the Dalgaard paper, which I don't have access to and which was written in the 1950's - a lot has changed since then. I'm a bit skeptical of this claim (a brief review of UpToDate and one or two other reviews didn't repeat a similar statement). Please, though, if anybody has a more recent reliable source, add it!
Wawot1 ( talk) 16:18, 19 June 2011 (UTC)
Somebody just made a radical change of meaning to a long-standing statement. I have no idea if it was an improvement. [1]
"Failure in flow-sensing signaling results in programmed cell death ( apoptosis) of these renal epithelial cells, producing the characteristic multiple cysts of PKD."
to
"Failure in flow-sensing signaling results in proliforation of these renal epithelial cells, producing the characteristic multiple cysts of PKD.
Reading the (free) source leaves me none the wiser. Someone who understands the topic should have a look. Anthonyhcole ( talk · contribs · email) 19:42, 16 January 2014 (UTC)
The article implies that tolvaptan isn't approved in the US, but it is. See the Aquaretic section. The phrase in question: "...the approval of the drug [tolvaptan] was either delayed by regulatory agencies or, as in case of the US, altogether denied." ― Biochemistry🙴❤ 14:24, 24 August 2018 (UTC)