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This article was the subject of a Wiki Education Foundation-supported course assignment, between 23 August 2021 and 10 December 2021. Further details are available on the course page. Student editor(s): Emilyreardon.
Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT ( talk) 14:28, 16 January 2022 (UTC)
Is there an opposite to anti-convulsants ie a medicine that blocks or destroys GABA or by any other way?
See http://www.reuters.com/article/idUSTRE63C4R020100413 and http://www.biopsychiatry.com/anticonvul.html
I think its worth mentioning that MANY anti-seizure DRUGS have never been APPROVED FOR CHILD USE by the (FDA) Food and Drug Administration in the United States. muncher 15:51, 23 October 2006 (UTC)
The licensing situation for children is complex and not unique to anticonvulsants. "One recent estimate was that 75 of the 80 medicines most commonly prescribed for newborns and infants were being prescribed off-label.".
[1] Licencing for children often specify several components:
The older drugs such as phenobarbital, ethosuximide and phenytoin are approved for children effectively by default (they were in use well before modern regulations). Here is the FDA approval status of some of the common modern drugs.
There is a wider choice of licensed drugs for children in the UK. [14] [15].
There remains a shortage of approved medicines for infants (under 2 years). Getting approval for monotherapy is hard, hence adjunctive therapy is established first. If enough off-licence usage is occurring, there is little incentive on the manufacturer to fund trials to widen the licence. What is interesting is that no epilepsy drugs have ever been compared against placebo (largely for ethical reasons) and that, within its indications, no epilepsy drug has ever been shown to be significantly better than any other (older) drug. Some may, however, be better tolerated. [16]
Perhaps some of this information could be added to the article. Colin° Talk 18:40, 23 October 2006 (UTC)
Jean P. Davis M.D., and H.H. Ramsey, M.D.
The demonstration of anticonvulsant activity of the tetrahydrocannabinol (THC) cogeners by laboratory tests (Loewe and Goodman, Federation Proc. 6:352, 1947) prompted clinical trial in five institutionalized epileptic children. All of them had symptomatic grand mal epilepsy with retardation; three has cerebral palsy in addition. EEG tracings were grossly abnormal in the entire group; three has focal seizure activity. Their attacks had been inadequately controlled on 0.13 gm. of Phenobarbital daily, combined with 0.3 gm. of Dilantin per day in two of the patients, and in a third, with 0.2 gm. of Mesantoin daily.
Two isomeric 3(1,2-dimethyl heptyl) homologs of THC were tested, numbers 122 and 125A, with ataxia potencies 50 and 8 times, respectively, that of natural Marijuana principles. Number 122 was given to 2 patients for 3 weeks and to 3 patients for 7 weeks. 3 responded at least as well to previous therapy; the 4th became almost completely and the 5th entirely seizure free. One patient transferred to 125A after 3 weeks, had prompt exacerbation of seizures during the ensuing 4 weeks, despite dosages up to 4 mg. daily. The 2nd patient transferred to 125A was adequately controlled on this dosage, except for a brief period of paranoid behavior three and a half weeks later; similar episodes had occurred prior to cannabinol therapy. Other psychic disturbances or toxic reactions were not manifested during the periods of treatment. Blood counts were normal. The cannabinoids herein reported deserve further trial in non-institutionalized epileptics. Reprinted from Federation Proceedings, Federation of American Society for Experimental Biology, vol 8, 1949, p.284.
These proceedings demonstrate unequivocally the Anticonvulsant properties of cannabinods. This is not opinion but fact and is therefore "absolute and non-negotiable" in accordance with WP:NPOV. Adding cannabinoids. Alphaquad 22:05, 19 March 2007 (UTC)
Therapeutic drug monitoring in epilepsy by PN Patsalos, NSE. Has a slightly different set of dates for UK drug introductions. Colin° Talk 21:49, 16 November 2007 (UTC)
Suggest adding Lacosamide (Vimpat). EU approval 9/3/08, US approval 10/29/08. — Preceding
unsigned comment added by
162.96.105.84 (
talk) 14:30, 25 July 2011 (UTC)
I am removing reference [2] and modifiying the sentence that antiepileptics cause cell death. This is wrong and taken out of context. It causes apoptosis in developing neurones, which means the effect is not seen in adult epileptics. I have read the reference and the group were looking at the effects of pregnant women taking AEDs by using postnatal rat models. The information is misleading to the extent that someone is asking about it in Yahoo answers. -- Mubinchoudhury ( talk) 21:41, 20 May 2008 (UTC)
This article is currently most a list, rather than sections with prose. I think there are benefits of having a list of such drugs but also of having an article discussing the drugs in general. Also many modern texts use the term antiepileptic drug (AED) rather than anticonvulsant. So I propose we create two articles:
Any objections? -- Colin° Talk 20:53, 24 February 2013 (UTC)
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Under the bromides section, there is a sentence that starts with "actually" and seems to go against a statement about dogs and cats made above. Can someone with knowledge about this subject clean this up? Thank you. William2001( talk) 05:30, 21 October 2019 (UTC)
I am Yaser GHAZAL a student in Üsküdar Üniversitesi in Istanbul Türkiye and Iam taking Special Topics in Neuroscience course with Dr. Öğr. Üyesi AYLA ARSLAN during summer course 2023 and editing this article is part of the tasks assigned to me so i ask for your support Yaser GHAZAL ( talk) 11:24, 23 August 2023 (UTC)
This article is rated C-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||||||||||||||||||||||
|
Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Anticonvulsant.
|
This article was the subject of a Wiki Education Foundation-supported course assignment, between 23 August 2021 and 10 December 2021. Further details are available on the course page. Student editor(s): Emilyreardon.
Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT ( talk) 14:28, 16 January 2022 (UTC)
Is there an opposite to anti-convulsants ie a medicine that blocks or destroys GABA or by any other way?
See http://www.reuters.com/article/idUSTRE63C4R020100413 and http://www.biopsychiatry.com/anticonvul.html
I think its worth mentioning that MANY anti-seizure DRUGS have never been APPROVED FOR CHILD USE by the (FDA) Food and Drug Administration in the United States. muncher 15:51, 23 October 2006 (UTC)
The licensing situation for children is complex and not unique to anticonvulsants. "One recent estimate was that 75 of the 80 medicines most commonly prescribed for newborns and infants were being prescribed off-label.".
[1] Licencing for children often specify several components:
The older drugs such as phenobarbital, ethosuximide and phenytoin are approved for children effectively by default (they were in use well before modern regulations). Here is the FDA approval status of some of the common modern drugs.
There is a wider choice of licensed drugs for children in the UK. [14] [15].
There remains a shortage of approved medicines for infants (under 2 years). Getting approval for monotherapy is hard, hence adjunctive therapy is established first. If enough off-licence usage is occurring, there is little incentive on the manufacturer to fund trials to widen the licence. What is interesting is that no epilepsy drugs have ever been compared against placebo (largely for ethical reasons) and that, within its indications, no epilepsy drug has ever been shown to be significantly better than any other (older) drug. Some may, however, be better tolerated. [16]
Perhaps some of this information could be added to the article. Colin° Talk 18:40, 23 October 2006 (UTC)
Jean P. Davis M.D., and H.H. Ramsey, M.D.
The demonstration of anticonvulsant activity of the tetrahydrocannabinol (THC) cogeners by laboratory tests (Loewe and Goodman, Federation Proc. 6:352, 1947) prompted clinical trial in five institutionalized epileptic children. All of them had symptomatic grand mal epilepsy with retardation; three has cerebral palsy in addition. EEG tracings were grossly abnormal in the entire group; three has focal seizure activity. Their attacks had been inadequately controlled on 0.13 gm. of Phenobarbital daily, combined with 0.3 gm. of Dilantin per day in two of the patients, and in a third, with 0.2 gm. of Mesantoin daily.
Two isomeric 3(1,2-dimethyl heptyl) homologs of THC were tested, numbers 122 and 125A, with ataxia potencies 50 and 8 times, respectively, that of natural Marijuana principles. Number 122 was given to 2 patients for 3 weeks and to 3 patients for 7 weeks. 3 responded at least as well to previous therapy; the 4th became almost completely and the 5th entirely seizure free. One patient transferred to 125A after 3 weeks, had prompt exacerbation of seizures during the ensuing 4 weeks, despite dosages up to 4 mg. daily. The 2nd patient transferred to 125A was adequately controlled on this dosage, except for a brief period of paranoid behavior three and a half weeks later; similar episodes had occurred prior to cannabinol therapy. Other psychic disturbances or toxic reactions were not manifested during the periods of treatment. Blood counts were normal. The cannabinoids herein reported deserve further trial in non-institutionalized epileptics. Reprinted from Federation Proceedings, Federation of American Society for Experimental Biology, vol 8, 1949, p.284.
These proceedings demonstrate unequivocally the Anticonvulsant properties of cannabinods. This is not opinion but fact and is therefore "absolute and non-negotiable" in accordance with WP:NPOV. Adding cannabinoids. Alphaquad 22:05, 19 March 2007 (UTC)
Therapeutic drug monitoring in epilepsy by PN Patsalos, NSE. Has a slightly different set of dates for UK drug introductions. Colin° Talk 21:49, 16 November 2007 (UTC)
Suggest adding Lacosamide (Vimpat). EU approval 9/3/08, US approval 10/29/08. — Preceding
unsigned comment added by
162.96.105.84 (
talk) 14:30, 25 July 2011 (UTC)
I am removing reference [2] and modifiying the sentence that antiepileptics cause cell death. This is wrong and taken out of context. It causes apoptosis in developing neurones, which means the effect is not seen in adult epileptics. I have read the reference and the group were looking at the effects of pregnant women taking AEDs by using postnatal rat models. The information is misleading to the extent that someone is asking about it in Yahoo answers. -- Mubinchoudhury ( talk) 21:41, 20 May 2008 (UTC)
This article is currently most a list, rather than sections with prose. I think there are benefits of having a list of such drugs but also of having an article discussing the drugs in general. Also many modern texts use the term antiepileptic drug (AED) rather than anticonvulsant. So I propose we create two articles:
Any objections? -- Colin° Talk 20:53, 24 February 2013 (UTC)
Hello fellow Wikipedians,
I have just modified 8 external links on Anticonvulsant. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
{{
dead link}}
tag to
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dead link}}
tag to
http://www.mdng.com/departments/2005-August/neuro_feature.htmWhen you have finished reviewing my changes, please set the checked parameter below to true or failed to let others know (documentation at {{
Sourcecheck}}
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This message was posted before February 2018.
After February 2018, "External links modified" talk page sections are no longer generated or monitored by InternetArchiveBot. No special action is required regarding these talk page notices, other than
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Cheers.— InternetArchiveBot ( Report bug) 16:02, 15 October 2016 (UTC)
Under the bromides section, there is a sentence that starts with "actually" and seems to go against a statement about dogs and cats made above. Can someone with knowledge about this subject clean this up? Thank you. William2001( talk) 05:30, 21 October 2019 (UTC)
I am Yaser GHAZAL a student in Üsküdar Üniversitesi in Istanbul Türkiye and Iam taking Special Topics in Neuroscience course with Dr. Öğr. Üyesi AYLA ARSLAN during summer course 2023 and editing this article is part of the tasks assigned to me so i ask for your support Yaser GHAZAL ( talk) 11:24, 23 August 2023 (UTC)