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Summaries of this article appear in Chromosome abnormalities and chromosome. |
Opening paragraph: "Chromosome abnormalities are detected in 1 of 160 live human births." I can't imagine why this wouldn't need a citation.
137.150.101.98 ( talk) 21:35, 3 October 2018 (UTC)
There is little more than a dicdef here; I propose moving the Haploidy, Diploidy, Haploidisation, Polyploidy, and Aneuploidy pages to Ploidy. You have to read all those articles to understand ploidy anywho. I'll be happy to do the merge after approvial. Lefty 16:02, 2005 Mar 12 (UTC)
I've heard tetraploidy can be almost as common as diploidy in some plants. Should this be addressed (ie- state that ploidy is relavent only when talking about a specific species. Or is ploidy definded as "natural is diploidy.") DavidMendoza 22:14, 9 Apr 2005 (UTC)
More specifically, in brains, perhaps in human brains.
-- Extremophile 23:29, 5 September 2006 (UTC)
It says on this page that trisomy 16 is the most common trisomy in humans. The trisomy 18 page, however, says that it is the second most common trisomy after Down Syndrome (trisomy 21).
Trisomy 16 is the most common at conception, but the fetuses spontaneously abort. Trisomy 21 is the most common in live births, followed by trisomy 18, with 16 way down the list because it's almost always very lethal.
I'm not an expert on using Wikipedia, nor am I an expert on this material, so I can't do it myself, but I wanted to add to this header since it talks about Trisomy 16. In the Aneuploidy article, Trisomy 16 is marked as always lethal in the chart in the "Types" section. However, the linked article to Trisomy 16 says with Trisomy 16 mosaicism, it is possible, albeit highly rare, for live births to occur. Can anyone double-check? A Cynical Asian ( talk) 07:13, 10 January 2016 (UTC)
This article (and the articles on cancer and carcinogenesis) does not appear to discuss the possible causal role of somatic cell aneuploidy in cancer. There's increasing speculation that a key step in the development of full-blown cancer is a chromosomal abnormality in a somatic cell, particularly if it produces chromosomal instability. It is noteworthy that every one of the heritable chromosomal instability disorders linked from that article is associated with elevated cancer risk and cancer in youth. —The preceding unsigned comment was added by 74.104.131.76 ( talk) 22:46, 28 April 2007 (UTC).
Panda, please address the arguments I've provided. Regarding your assertion about the non-existence of reliable sources in this otherwise unsourced article, see e.g. :
Avb 17:42, 11 December 2007 (UTC)
Editors should provide a reliable source for ... any material that is challenged or is likely to be challenged, or it may be removed.
I work in clinical genetics, and I have never heard the term trisomy 23. I don't think this should be used. Kxw1 ( talk) 19:38, 19 December 2007 (UTC)
I don't think that Cri du Chat and 1p36 deletion should be in this article. Aneuploidy is defined as "having or being a chromosome number that is not an exact multiple of the usually haploid number" ( http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=aneuploidy). Deletions are not numerical but structural changes. While they can result in "partial monosomy", they are not generally thought of as aneuploid. I think these should be moved to a separate article on structural chromosome changes or chromosome microdeletions, if one exists. Kxw1 ( talk) 19:43, 19 December 2007 (UTC)
This is a pretty good treatment of aneuploidy in humans, but that's a very limited view of the topic. I'd like to work on getting some information on other species in here. For now, perhaps the best way to do this without disrupting the organization of the page is to simply add a section on "aneuploidy in other organisms"? Agathman ( talk) 17:51, 26 May 2009 (UTC)
It's always been my understanding that multiple sex chromosomes (especially multiple X's) causes mental/cognitive underdevelopment. Has anyone any idea why this might be? Chbse 12:37, 19 June 2010 (UTC) —Preceding unsigned comment added by Chbse ( talk • contribs)
The first sentence of this page has been repeatedly changed to an inaccurate one by an editor who cites WP:NOTJOURNAL as their rationale. Please see Wikipedia_talk:What_Wikipedia_is_not#This_page_being_used_to_support_wikilawyering for further discussion. Sminthopsis84 ( talk) 13:03, 24 April 2015 (UTC)
To explain further, since the policy talk entry has become bogged down in discussing the content here, here are the two versions of the first sentence (or two) of the page:
The presence and lack of links are as in the originals.
Okay found refs now that I have internet. "Ananeuploid is an individual organism whose chromosome number differs from the wild type by part of a chromosome set." [1] Doc James ( talk · contribs · email) 15:44, 26 April 2015 (UTC)
Have clarified. We have "Aneuploidy is the presence in a cell of an abnormal number of chromosomes" with this being the exception to that rule "with the exception of a difference of one or more complete sets of chromosomes" Doc James ( talk · contribs · email) 14:37, 27 April 2015 (UTC)
It might be better to use multiple short sentences:
Aneuploidy is the presence of an abnormal number of chromosomes in a cell, such as having 45 or 47 chromosomes in a cell when 46 is expected. It does not include having one or more complete sets of chromosomes, which is usually called polyploidy. An extra or missing chromosome is a common cause of genetic disorders, including some human birth defects. Some cancer cells also have abnormal numbers of chromosomes.
It's too complicated if you try to cram all of that into a single sentence. WhatamIdoing ( talk) 00:19, 29 April 2015 (UTC)
The comment(s) below were originally left at Talk:Aneuploidy/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.
Rated "high" because "trisomy" redirects here and is highschool/SAT biology content. - tameeria 03:01, 29 April 2007 (UTC) |
Last edited at 03:01, 29 April 2007 (UTC). Substituted at 07:47, 29 April 2016 (UTC)
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This section appears to be referenced well and described neutrally. However, as a layman, I'm concerned that "exposure" is used throughout the text in a vague qualitative way. Can someone insert exposure LEVELS noted in the various articles cited? Martindo ( talk) 00:42, 31 May 2020 (UTC)
I think it's a polysomy with respect to Y, not a normal state. Alfa-ketosav ( talk) 16:10, 21 January 2021 (UTC)
This article is rated B-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: |
||||||||||||||||||||||||||||||
|
To-do list for Aneuploidy:
Priority 4
|
Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Aneuploidy.
|
Summaries of this article appear in Chromosome abnormalities and chromosome. |
Opening paragraph: "Chromosome abnormalities are detected in 1 of 160 live human births." I can't imagine why this wouldn't need a citation.
137.150.101.98 ( talk) 21:35, 3 October 2018 (UTC)
There is little more than a dicdef here; I propose moving the Haploidy, Diploidy, Haploidisation, Polyploidy, and Aneuploidy pages to Ploidy. You have to read all those articles to understand ploidy anywho. I'll be happy to do the merge after approvial. Lefty 16:02, 2005 Mar 12 (UTC)
I've heard tetraploidy can be almost as common as diploidy in some plants. Should this be addressed (ie- state that ploidy is relavent only when talking about a specific species. Or is ploidy definded as "natural is diploidy.") DavidMendoza 22:14, 9 Apr 2005 (UTC)
More specifically, in brains, perhaps in human brains.
-- Extremophile 23:29, 5 September 2006 (UTC)
It says on this page that trisomy 16 is the most common trisomy in humans. The trisomy 18 page, however, says that it is the second most common trisomy after Down Syndrome (trisomy 21).
Trisomy 16 is the most common at conception, but the fetuses spontaneously abort. Trisomy 21 is the most common in live births, followed by trisomy 18, with 16 way down the list because it's almost always very lethal.
I'm not an expert on using Wikipedia, nor am I an expert on this material, so I can't do it myself, but I wanted to add to this header since it talks about Trisomy 16. In the Aneuploidy article, Trisomy 16 is marked as always lethal in the chart in the "Types" section. However, the linked article to Trisomy 16 says with Trisomy 16 mosaicism, it is possible, albeit highly rare, for live births to occur. Can anyone double-check? A Cynical Asian ( talk) 07:13, 10 January 2016 (UTC)
This article (and the articles on cancer and carcinogenesis) does not appear to discuss the possible causal role of somatic cell aneuploidy in cancer. There's increasing speculation that a key step in the development of full-blown cancer is a chromosomal abnormality in a somatic cell, particularly if it produces chromosomal instability. It is noteworthy that every one of the heritable chromosomal instability disorders linked from that article is associated with elevated cancer risk and cancer in youth. —The preceding unsigned comment was added by 74.104.131.76 ( talk) 22:46, 28 April 2007 (UTC).
Panda, please address the arguments I've provided. Regarding your assertion about the non-existence of reliable sources in this otherwise unsourced article, see e.g. :
Avb 17:42, 11 December 2007 (UTC)
Editors should provide a reliable source for ... any material that is challenged or is likely to be challenged, or it may be removed.
I work in clinical genetics, and I have never heard the term trisomy 23. I don't think this should be used. Kxw1 ( talk) 19:38, 19 December 2007 (UTC)
I don't think that Cri du Chat and 1p36 deletion should be in this article. Aneuploidy is defined as "having or being a chromosome number that is not an exact multiple of the usually haploid number" ( http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=aneuploidy). Deletions are not numerical but structural changes. While they can result in "partial monosomy", they are not generally thought of as aneuploid. I think these should be moved to a separate article on structural chromosome changes or chromosome microdeletions, if one exists. Kxw1 ( talk) 19:43, 19 December 2007 (UTC)
This is a pretty good treatment of aneuploidy in humans, but that's a very limited view of the topic. I'd like to work on getting some information on other species in here. For now, perhaps the best way to do this without disrupting the organization of the page is to simply add a section on "aneuploidy in other organisms"? Agathman ( talk) 17:51, 26 May 2009 (UTC)
It's always been my understanding that multiple sex chromosomes (especially multiple X's) causes mental/cognitive underdevelopment. Has anyone any idea why this might be? Chbse 12:37, 19 June 2010 (UTC) —Preceding unsigned comment added by Chbse ( talk • contribs)
The first sentence of this page has been repeatedly changed to an inaccurate one by an editor who cites WP:NOTJOURNAL as their rationale. Please see Wikipedia_talk:What_Wikipedia_is_not#This_page_being_used_to_support_wikilawyering for further discussion. Sminthopsis84 ( talk) 13:03, 24 April 2015 (UTC)
To explain further, since the policy talk entry has become bogged down in discussing the content here, here are the two versions of the first sentence (or two) of the page:
The presence and lack of links are as in the originals.
Okay found refs now that I have internet. "Ananeuploid is an individual organism whose chromosome number differs from the wild type by part of a chromosome set." [1] Doc James ( talk · contribs · email) 15:44, 26 April 2015 (UTC)
Have clarified. We have "Aneuploidy is the presence in a cell of an abnormal number of chromosomes" with this being the exception to that rule "with the exception of a difference of one or more complete sets of chromosomes" Doc James ( talk · contribs · email) 14:37, 27 April 2015 (UTC)
It might be better to use multiple short sentences:
Aneuploidy is the presence of an abnormal number of chromosomes in a cell, such as having 45 or 47 chromosomes in a cell when 46 is expected. It does not include having one or more complete sets of chromosomes, which is usually called polyploidy. An extra or missing chromosome is a common cause of genetic disorders, including some human birth defects. Some cancer cells also have abnormal numbers of chromosomes.
It's too complicated if you try to cram all of that into a single sentence. WhatamIdoing ( talk) 00:19, 29 April 2015 (UTC)
The comment(s) below were originally left at Talk:Aneuploidy/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.
Rated "high" because "trisomy" redirects here and is highschool/SAT biology content. - tameeria 03:01, 29 April 2007 (UTC) |
Last edited at 03:01, 29 April 2007 (UTC). Substituted at 07:47, 29 April 2016 (UTC)
Hello fellow Wikipedians,
I have just modified 2 external links on Aneuploidy. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
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Cheers.— InternetArchiveBot ( Report bug) 20:45, 13 October 2016 (UTC)
This section appears to be referenced well and described neutrally. However, as a layman, I'm concerned that "exposure" is used throughout the text in a vague qualitative way. Can someone insert exposure LEVELS noted in the various articles cited? Martindo ( talk) 00:42, 31 May 2020 (UTC)
I think it's a polysomy with respect to Y, not a normal state. Alfa-ketosav ( talk) 16:10, 21 January 2021 (UTC)